吸烟与心房颤动患者的脑结构缺陷

IF 2.3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Raffaele Peter, Stefanie Aeschbacher, Rebecca E Paladini, Michael Coslovsky, Philipp Krisai, Adrian Schweigler, Tobias Reichlin, Nicolas Rodondi, Andreas Müller, Moa Haller, Merit Röhl, Annina Stauber, Tim Sinnecker, Leo H Bonati, Thilo Burkard, David Conen, Stefan Osswald, Michael Kühne, Christine S Zuern
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引用次数: 0

摘要

简介吸烟和心房颤动(房颤)与大脑健康受损有关。我们研究了房颤患者的吸烟习惯、脑部病变和脑容量之间的关系:在一项多中心队列研究中,我们对心房颤动患者的吸烟状况(从不吸烟、曾经吸烟、积极吸烟)、每天吸烟支数(cpd)、吸烟时间(年)、吸烟包年(pky)和戒烟时间进行了评估。脑磁共振成像评估了白质病变(WML)和小非皮质梗死(SNCI)的发生率和体积,以及灰质(GM)和白质(WM)的体积。采用逻辑和线性回归分析法分析吸烟习惯、脑部病变和体积之间的关系:共有 1728 名患者(平均年龄 72.6 岁,女性占 27.5%)参加了研究。7.5%的患者为主动吸烟者,48.5%为戒烟者,44%为从不吸烟者。我们发现,cpd、pky和戒烟年龄越大,GM体积越小(线性趋势的p为3(-0.8; -0.11),p=0.01):总之,吸烟强度和戒烟时间与房颤患者脑部病变的存在和体积以及脑容量有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cigarette Smoking and Structural Brain Deficits in Patients With Atrial Fibrillation.

Cigarette smoking and atrial fibrillation (AF) are associated with impaired brain health. We investigated the association between smoking habits and brain lesions and volume in patients with AF. In patients with AF from a multicenter cohort study, we assessed smoking status (never, ex-, active), number of cigarettes smoked per day, smoking duration (years), pack-years, and time since smoking cessation. On brain magnetic resonance imaging, the prevalence and volumes of white matter lesions (WML) and small noncortical infarcts, and the volumes of gray matter and white matter were evaluated. Logistic and linear regression analyses were used to analyze the association between smoking habits and brain lesions and volumes. A total of 1,728 patients were enrolled (mean age 72.6 years, 27.5% female); 7.5% were active smokers; 48.5% were ex-smokers, and 44% had never smoked. We found linear associations of number of cigarettes smoked per day, pack-years, and older age at smoking cessation with reduced gray matter volume (p for linear trend <0.01, 0.02, and 0.01, respectively). Patients with a smoking duration in the second and third tertile had a greater risk for WML Fazekas ≥2 (odds ratio 1.86, 95% confidence interval 1.29 to 2.69, p <0.01 and 1.47 [1.02 to 2.12], p = 0.04), and exhibited larger WML volumes. Patients who had stopped smoking ≥16 years before enrollment were less likely to have small noncortical infarcts (odds ratio 0.46, 0.25 to 0.88, p = 0.02) and had smaller WML volumes (β: -0.451 mm3, -0.8 to -0.11, p = 0.01). In conclusion, smoking intensity and time since smoking cessation were associated with the presence and volume of brain lesions and with brain volumes in patients with AF.

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来源期刊
American Journal of Cardiology
American Journal of Cardiology 医学-心血管系统
CiteScore
4.00
自引率
3.60%
发文量
698
审稿时长
33 days
期刊介绍: Published 24 times a year, The American Journal of Cardiology® is an independent journal designed for cardiovascular disease specialists and internists with a subspecialty in cardiology throughout the world. AJC is an independent, scientific, peer-reviewed journal of original articles that focus on the practical, clinical approach to the diagnosis and treatment of cardiovascular disease. AJC has one of the fastest acceptance to publication times in Cardiology. Features report on systemic hypertension, methodology, drugs, pacing, arrhythmia, preventive cardiology, congestive heart failure, valvular heart disease, congenital heart disease, and cardiomyopathy. Also included are editorials, readers'' comments, and symposia.
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