古人类混居及其对现代人类的影响。

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2024-11-21 DOI:10.1016/j.gde.2024.102280

Debashree Tagore, Joshua M Akey

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引用次数: 0

摘要

随着解剖学上的现代人走出非洲，他们遇到了现已灭绝的类人猿，包括尼安德特人和丹尼索瓦人，并与之交配。现在可以确定的是，所有非非洲人的基因组中约有 2% 来自尼安德特人的祖先，而美拉尼西亚人和澳大利亚原住民祖先的基因组中又有 2%-5% 来自丹尼索瓦人的祖先。人们的注意力已开始从记录古老混血的数量和识别导入片段转向了解其分子、表型和进化后果以及完善人类历史模型。在这里，我们回顾了最近对现代人与古人类之间的混杂的见解，强调了方法的创新以及尼安德特人和丹尼索瓦人序列在当代个体中的功能和表型效应。

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Archaic hominin admixture and its consequences for modern humans

As anatomically modern humans dispersed out of Africa, they encountered and mated with now extinct hominins, including Neanderthals and Denisovans. It is now well established that all non-African individuals derive approximately 2% of their genome from Neanderthal ancestors and individuals of Melanesian and Australian aboriginal ancestry inherited an additional 2%–5% of their genomes from Denisovan ancestors. Attention has started to shift from documenting amounts of archaic admixture and identifying introgressed segments to understanding their molecular, phenotypic, and evolutionary consequences and refining models of human history. Here, we review recent insights into admixture between modern and archaic humans, emphasizing methodological innovations and the functional and phenotypic effects Neanderthal and Denisovan sequences have in contemporary individuals.

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)