血泡样动脉瘤手术中术中神经电生理监测的高假阴性率:回顾性病例系列的启示。

IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY
Yue Hu, Lu Ma, Yixuan Zong, Xiaofan Pang, Yuan Fang
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引用次数: 0

摘要

目的:血泡样动脉瘤(BBA)的手术治疗因其发病率和死亡率高而具有挑战性和争议性。术中神经电生理监测(IONM)是颅内动脉瘤手术中一种行之有效的工具,但其在血泡样动脉瘤手术中的应用尚未见报道。本研究回顾性分析了2018年至2023年间IONM在BBA手术中的应用:我们利用体感和经颅运动诱发电位(SSEPs/tcMEPs)监测手术过程中的缺血情况。主要通过每日格拉斯哥昏迷量表、24小时内的计算机断层扫描和出院时的改良Rankin量表来评估神经系统结果:13 名 BBA 破裂患者(9 名藏族,4 名汉族;10 名女性,3 名男性;平均年龄:55 岁)接受了 10 次剪切(6 次直接剪切,2 次包裹辅助剪切,2 次球囊辅助剪切)和 3 次牵引的手术。其中 8 次剪切手术应用了 5 至 125 分钟不等的临时动脉闭塞。有 3 例剪切发生了 SSEPs/tcMEPs 的不可逆变化,术后均出现了神经功能缺损。3 例剪切发生了 SSEPs 的可逆信号变化(RSC),其中 1 例出现神经功能缺损。至于 3 例诱捕手术,无论 IONM 中的 RSC 还是信号不变,均表现出明显的功能障碍:我们的研究结果表明,IONM 在检测 BBA 手术中的缺血事件方面具有较低的灵敏度(37.5%)和较高的特异性(100%)。BBA-IONM的假阴性结果率很高,这表明其预测价值有限,尤其是在诱捕和高级血管重建等复杂操作中,因此需要谨慎解释并进一步研究用于BBA管理的IONM模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High False-Negative Rate of Intraoperative Neurophysiologic Monitoring in Blood Blister-Like Aneurysm Surgery: Insights from a Retrospective Case Series.

Objective: Surgical management of blood blister-like aneurysm (BBA) is challenging and contentious because of high morbidity and mortality. Intraoperative neurophysiologic monitoring (IONM) is a well-established tool in intracranial aneurysm surgery, although its application in BBA surgery lacks reports. This study retrospectively analyzes the usefulness of IONM in BBA surgery between 2018 and 2023.

Methods: We used somatosensory evoked potentials (SSEPs) and transcranial motor evoked potentials to monitor ischemia during operations. Neurologic outcomes were mainly assessed through daily assessment with the Glasgow Coma Scale, computed tomography within 24 hours, and modified Rankin Scale at discharge.

Results: Thirteen patients with ruptured BBAs (9 Tibetan, 4 Han; 10 women, 3 men; mean age, 55 years) underwent surgical procedures involving 10 clippings (6 direct, 2 wrapping-assisted, and 2 balloon-assisted) and 3 trappings. There were 8 clipping procedures applied for temporary arterial occlusion ranging from 5 to 125 minutes. Irreversible change of SSEPs/transcranial motor evoked potential (tcMEPs) occurred in 3 clippings; all these patients developed postoperative neurologic deficits. Reversible signal change of SSEPs occurred in 3 clippings, with 1 neurologic deficit. As for 3 trapping surgeries, all showed significant deficits regardless of reversible signal change or unchanged signals in IONM.

Conclusions: Our results show that IONM has low sensitivity (37.5%) and high specificity (100%) in detecting ischemic events during BBA surgery. The high rate of false-negative results in BBA-IONM suggests that its predictive value is limited particularly in complex maneuvers such as trapping and advanced vasoreconstruction, warranting cautious interpretation and further investigation of IONM modalities for BBA management.

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来源期刊
World neurosurgery
World neurosurgery CLINICAL NEUROLOGY-SURGERY
CiteScore
3.90
自引率
15.00%
发文量
1765
审稿时长
47 days
期刊介绍: World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal''s mission is to: -To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care. -To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide. -To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients. Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS
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