髋部骨折老年患者的全身免疫炎症指数和 2 年全因死亡率。

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2024-11-10 DOI:10.1016/j.archger.2024.105695

Shuhuai Tan , Yu Jiang , Kaihua Qin , Yan Luo , Dingfa Liang , Yong Xie , Xiang Cui , Junsong Wang , Houchen Lyu , Licheng Zhang

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引用次数: 0

摘要

目的：评估髋部骨折老年患者的全身免疫炎症指数（SII）与2年全因死亡率之间的关系：我们对 2005 年 1 月至 2022 年 3 月期间在一家三级医院接受髋部骨折手术的 65 岁或以上髋部骨折患者进行了一项队列研究。SII 的计算公式为SII=（中性粒细胞计数*血小板计数）/淋巴细胞计数，以出院前最近一次血液检测结果为准。根据 SII 三等分法将患者分为三组：低 SII 组（≤770.92 × 109/L）、中 SII 组（770.92 × 109/L -1293.03 × 109/L）和高 SII 组（>1293.03 × 109/L）。主要结果是 2 年全因死亡率。我们使用多变量 Cox 回归模型评估了 SII 与 2 年全因死亡率之间的关系：结果：在 2766 名患者中，有 296 名患者在 2 年随访期间死亡。低 SII 组每千人 2 年全因死亡率为 90.0（95 % CI：73.2-110.2），中 SII 组为 86.8（95 % CI：70.3-106.7），高 SII 组为 144.3（95 % CI：123.1-168.5）。与低 SII 组患者相比，中 SII 组患者 2 年全因死亡率的危险比为 0.97（95 % CI：0.69-1.37），高 SII 组患者 2 年全因死亡率的危险比为 1.47（95 % CI：1.07-2.01）（P 为趋势，0.010）：结论：SII与老年髋部骨折患者的2年全因死亡率密切相关。结论：SII 与老年髋部骨折患者的 2 年全因死亡率密切相关，SII 可用于识别髋部骨折手术后的高危患者。

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Systemic immune-inflammation index and 2-year all-cause mortality in elderly patients with hip fracture

Purpose

To assess the association between systemic immune-inflammation index (SII) and 2-year all-cause mortality in elderly patients with hip fractures.

Methods

We performed a cohort study of hip fracture patients aged 65 years or older who received hip fracture surgery at a tertiary hospital from January 2005 to March 2022. The SII was calculated as: SII = (neutrophil count * platelet count) / lymphocyte count, based on the latest blood test before discharge. Patients were categorized into 3 groups according to SII tertiles: low SII group (≤770.92 × 10⁹/L), medium SII group (770.92 × 10⁹/L -1293.03 × 10⁹/L), and high SII group (>1293.03 × 10⁹/L). The primary outcome was 2-year all-cause mortality. We evaluated the association between SII and 2-year all-cause mortality using the multivariate Cox regression model.

Results

Among 2766 patients, 296 patients died during the 2-year follow-up period. The incidence of 2-year all-cause mortality per 1000 persons was 90.0 (95 % CI: 73.2–110.2) in the low SII group, 86.8 (95 % CI: 70.3–106.7) in the medium SII group, and 144.3 (95 % CI: 123.1–168.5) in the high SII group. Compared with patients in the low SII group, the hazard ratio for 2-year all-cause mortality was 0.97 (95 % CI: 0.69–1.37) in the medium SII group and 1.47 (95 % CI: 1.07–2.01) in the high SII group (P for trend, 0.010).

Conclusion

SII is significantly associated with 2-year all-cause mortality in elderly patients with hip fracture. SII may be used to identify patients at high risk of mortality after hip fracture surgery.

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.