Daniel Thompson, Adam Williams, Peter Hutchinson, Adel Helmy, David Cromwell
{"title":"回顾科克伦系统回顾数据库中的神经外科 RCT:主要发现及对未来研究的启示。","authors":"Daniel Thompson, Adam Williams, Peter Hutchinson, Adel Helmy, David Cromwell","doi":"10.1016/j.wneu.2024.11.054","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Evidence available to clinicians and patients to inform treatment decisions is ideally produced by randomized controlled trials (RCTs). The objective of this study was to assess the extent to which neurosurgical practice is supported by RCT-level evidence.</p><p><strong>Methods: </strong>A search of the Cochrane Library was conducted to find reviews of the effectiveness of neurosurgical operative interventions. Data were extracted on the intervention, patient population, and outcome measures as well as the strength of evidence, as rated by the Cochrane authors. The extracted data were analyzed to identify the gaps and areas of (in)consistency across the RCTs included within the Cochrane Reviews.</p><p><strong>Results: </strong>A total of 52 Cochrane Reviews met the inclusion criteria, which covered 8 neurosurgical subspecialties. However, only 28 were published after 2015. There was limited coverage of multiple commonly performed neurosurgical interventions and 9 reviews found no RCTs related to their selected topic. In 28 reviews, results were synthesized from 5 or fewer trials. Primary outcomes also varied among trials examining similar interventions. The overall quality rating of the evidence for the different subspecialties varied, with the majority of reviews rating the evidence as being from very low to low.</p><p><strong>Conclusions: </strong>The RCT-level evidence supporting neurosurgical practice is varied and the outcomes tested remain predominantly heterogeneous. There remain important neurosurgical conditions where treatment strategies are not underpinned by high-quality evidence. Pragmatic RCTs, well-designed observational studies as well as robust audit and registry processes may provide the real-world evidence for treatment decisions in neurosurgical care.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"123471"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Review of Neurosurgical randomized controlled trials in the Cochrane Database of Systematic Reviews: Key Findings and Implications for Future Research.\",\"authors\":\"Daniel Thompson, Adam Williams, Peter Hutchinson, Adel Helmy, David Cromwell\",\"doi\":\"10.1016/j.wneu.2024.11.054\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Evidence available to clinicians and patients to inform treatment decisions is ideally produced by randomized controlled trials (RCTs). The objective of this study was to assess the extent to which neurosurgical practice is supported by RCT-level evidence.</p><p><strong>Methods: </strong>A search of the Cochrane Library was conducted to find reviews of the effectiveness of neurosurgical operative interventions. Data were extracted on the intervention, patient population, and outcome measures as well as the strength of evidence, as rated by the Cochrane authors. The extracted data were analyzed to identify the gaps and areas of (in)consistency across the RCTs included within the Cochrane Reviews.</p><p><strong>Results: </strong>A total of 52 Cochrane Reviews met the inclusion criteria, which covered 8 neurosurgical subspecialties. However, only 28 were published after 2015. There was limited coverage of multiple commonly performed neurosurgical interventions and 9 reviews found no RCTs related to their selected topic. In 28 reviews, results were synthesized from 5 or fewer trials. Primary outcomes also varied among trials examining similar interventions. The overall quality rating of the evidence for the different subspecialties varied, with the majority of reviews rating the evidence as being from very low to low.</p><p><strong>Conclusions: </strong>The RCT-level evidence supporting neurosurgical practice is varied and the outcomes tested remain predominantly heterogeneous. There remain important neurosurgical conditions where treatment strategies are not underpinned by high-quality evidence. Pragmatic RCTs, well-designed observational studies as well as robust audit and registry processes may provide the real-world evidence for treatment decisions in neurosurgical care.</p>\",\"PeriodicalId\":23906,\"journal\":{\"name\":\"World neurosurgery\",\"volume\":\" \",\"pages\":\"123471\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-12-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World neurosurgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.wneu.2024.11.054\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.wneu.2024.11.054","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
A Review of Neurosurgical randomized controlled trials in the Cochrane Database of Systematic Reviews: Key Findings and Implications for Future Research.
Objective: Evidence available to clinicians and patients to inform treatment decisions is ideally produced by randomized controlled trials (RCTs). The objective of this study was to assess the extent to which neurosurgical practice is supported by RCT-level evidence.
Methods: A search of the Cochrane Library was conducted to find reviews of the effectiveness of neurosurgical operative interventions. Data were extracted on the intervention, patient population, and outcome measures as well as the strength of evidence, as rated by the Cochrane authors. The extracted data were analyzed to identify the gaps and areas of (in)consistency across the RCTs included within the Cochrane Reviews.
Results: A total of 52 Cochrane Reviews met the inclusion criteria, which covered 8 neurosurgical subspecialties. However, only 28 were published after 2015. There was limited coverage of multiple commonly performed neurosurgical interventions and 9 reviews found no RCTs related to their selected topic. In 28 reviews, results were synthesized from 5 or fewer trials. Primary outcomes also varied among trials examining similar interventions. The overall quality rating of the evidence for the different subspecialties varied, with the majority of reviews rating the evidence as being from very low to low.
Conclusions: The RCT-level evidence supporting neurosurgical practice is varied and the outcomes tested remain predominantly heterogeneous. There remain important neurosurgical conditions where treatment strategies are not underpinned by high-quality evidence. Pragmatic RCTs, well-designed observational studies as well as robust audit and registry processes may provide the real-world evidence for treatment decisions in neurosurgical care.
期刊介绍:
World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
The journal''s mission is to:
-To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care.
-To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide.
-To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients.
Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS