通过诱导血管化提高肾脏类器官的成熟度：体外建模又向前迈进了一步。

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2024-11-20 DOI:10.1016/j.kint.2024.09.013

Lori L. O’Brien

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引用次数: 0

摘要

肾脏器官组织是一种有形的体外系统，可用于建立疾病模型、鉴定新型疗法以及研究细胞和生理机制。然而，它们的相对不成熟和关键细胞类型的不足限制了它们的转化功效。针对这些不足，Maggiore 等人提出了一种新型基因诱导血管化肾脏类器官模型。类器官形成了具有肾脏特异性特征的强大内皮网络，可提高荚膜细胞的成熟度并支持功能性肾素+细胞的生成。

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Enhancing kidney organoid maturity with inducible vascularization: another step forward for in vitro modeling

Kidney organoids represent a tangible in vitro system in which to model disease, identify novel therapeutics, and investigate cellular and physiological mechanisms. However, their relative immaturity and insufficient endowment of critical cell types limits their translational efficacy. Addressing a number of these shortcomings, Maggiore et al. present a novel genetically inducible vascularized kidney organoid model. Organoids develop a robust endothelial network with kidney-specific features that enhances podocyte maturity and supports the generation of functional renin+ cells.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.