怀有土著和/或托雷斯海峡岛民婴儿的妇女的可溶性（原）肾素受体（s(P)RR）水平；Gomeroi Gaaynggal 研究。

IF 2.5 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health Pub Date : 2024-11-21 DOI:10.1016/j.preghy.2024.101169

Saije K. Endacott , Cassandra Brennan , Richard G.S. Kahl , Oyepeju M. Onifade , Kym M. Rae , Eugenie R. Lumbers , Kirsty G. Pringle , The Gomeroi Gaaynggal Advisory Committee

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引用次数: 0

摘要

目的确定怀有土著居民和/或托雷斯海峡岛民（原住民）婴儿的妇女体内可溶性（原）肾素受体（s(P)RR）的水平，并调查s(P)RR水平在复杂妊娠妇女体内是否会发生变化：横断面数据分析（2010-2018 年）。数据/样本来自 Gomeroi Gaaynggal 研究，这是一项基于澳大利亚新南威尔士州 Gomeroi/Kamilaroi 土地（塔姆沃思）的纵向队列研究。第三孕期样本（血液/尿液）采集自怀有原住民婴儿的孕妇（N = 188）：血浆 s(P)RR 和肾功能指标（血浆：肌酐、尿素和胱抑素 C；尿液：肌酐、蛋白质、白蛋白、血管紧张素原、肾素和 Na/K）根据需要通过酶联免疫吸附试验或标准化病理学程序进行测量：队列中女性的血浆中检测到了可溶性（P）RR（中位数：19.86 ng/mL；IQR：12.52-26.8）。可溶性 (P)RR 水平与孕产妇血浆肌酐（P = 0.0001）和第三孕期孕龄（P = 0.002）呈正相关。s(P)RR 水平与尿蛋白/肌酐（P = 0.04）和肾素/肌酐（P = 0.03）呈正相关。早产妇女的可溶性 (P)RR 水平往往更高（P = 0.06）。可溶性（P）RR水平与其他妊娠并发症或结果（子痫前期、糖尿病、小胎龄或大胎龄分娩）无关：结论：可溶性（P）RR 存在于怀有原住民婴儿的孕妇血浆中，并与已知的肾功能尿液生物标志物相关。母体可溶性（P）RR水平的增加可能与早产风险的增加有关。

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Soluble (pro)renin receptor (s(P)RR) levels in women carrying Aboriginal and/or Torres Strait Islander babies; the Gomeroi Gaaynggal study

Objective

To determine the levels of soluble (pro)renin receptor (s(P)RR) in women carrying Aboriginal and/or Torres Strait Islander (First Nations) babies and investigate whether s(P)RR levels change in women who have complicated pregnancies.

Study Design

Cross-sectional analysis of data (2010–2018). Data/samples were from the Gomeroi Gaaynggal Study, a longitudinal cohort study based on Gomeroi/Kamilaroi lands (Tamworth), NSW, Australia. Third trimester samples (blood/urine) were collected from pregnant women carrying a First Nations baby (N = 188).

Methods/Main outcome measures

Plasma s(P)RR and markers of kidney function (plasma: creatinine, urea and cystatin C; urinary: creatinine, protein, albumin, angiotensinogen, nephrin and Na/K) were measured by enzyme-linked immunosorbent assay or standardised pathology procedures as needed.

Results

Soluble (P)RR was detected in plasma of women in the cohort (median: 19.86 ng/mL; IQR: 12.52–26.8). Soluble (P)RR levels correlated positively with maternal plasma creatinine (P = 0.0001) and gestational age in the third trimester (P = 0.002). Levels of s(P)RR tended to positively correlate with urinary protein/creatinine (P = 0.04) and nephrin/creatinine (P = 0.03). Soluble (P)RR levels tended to be higher in women who birthed prematurely (P = 0.06). Soluble (P)RR levels did not change with other pregnancy complications or outcomes (preeclampsia, GDM or small or large for gestational age birth).

Conclusions

Soluble (P)RR is present in the plasma of pregnant women carrying First Nations babies and is correlated with known urinary biomarkers of renal function. Increased maternal s(P)RR levels may be associated with increased risk of preterm birth.

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来源期刊

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health OBSTETRICS & GYNECOLOGYPERIPHERAL VASCULAR-PERIPHERAL VASCULAR DISEASE

CiteScore

4.90

自引率

0.00%

发文量

127

期刊介绍： Pregnancy Hypertension: An International Journal of Women''s Cardiovascular Health aims to stimulate research in the field of hypertension in pregnancy, disseminate the useful results of such research, and advance education in the field. We publish articles pertaining to human and animal blood pressure during gestation, hypertension during gestation including physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy. The subtitle reflects the wider aspects of studying hypertension in pregnancy thus we also publish articles on in utero programming, nutrition, long term effects of hypertension in pregnancy on cardiovascular health and other research that helps our understanding of the etiology or consequences of hypertension in pregnancy. Case reports are not published unless of exceptional/outstanding importance to the field.