D 型人格特征的代谢组学分析。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2024-11-19 DOI:10.1016/j.jpsychores.2024.111994

Ruifang Li-Gao , Mariska Bot , Alexander Kurilshikov , Gonneke Willemsen , Marleen M.J. van Greevenbroek , Miranda M.T. Schram , Coen D.A. Stehouwer , Jingyuan Fu , Alexandra Zhernakova , Brenda W.J.H. Penninx , Eco J.C. De Geus , Dorret I. Boomsma , Nina Kupper , for the BBMRI-NL Metabolomics Consortium

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引用次数: 0

摘要

目的D型（压抑型）人格结合了负性情感（NA）和社交抑制（SI），与心血管代谢疾病风险的增加有关。在此，我们研究了 D 型性格与 230 种（主要是）脂质代谢物和代谢物比率的关系：方法：纳入了四个荷兰队列，共 10834 人。D型人格特征通过自我报告问卷进行测量。质子核磁共振（NMR）代谢组学平台提供了 149 个绝对测量值（98 个属于脂蛋白亚类）和 81 个衍生比率。在每个队列中对所有数据进行线性回归分析，然后进行随机效应荟萃分析。每项测量的 FDR q 值结果：SI 与较低的ω-3 脂肪酸与总脂肪酸（FAw3.FA%）比率和较低的游离胆固醇与极小 VLDL 总脂类比率（XS.VLDL.FC%）明显相关。FAw3.FA%也与NA有关（但在研究上没有意义）。NA显示出提示性复制（p-value结论：在这项大型荟萃分析中，SI 与欧米伽-3 脂肪酸与总脂肪酸的比率有关，这表明欧米伽-3 脂肪酸的摄入量较低。只有一些代谢物生物标志物与 D 型和 NA 型有初步联系。总之，脂质代谢似乎没有与 D 型特征相关的重大改变。

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Metabolomics profiling of Type D personality traits

Objective

Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, we examined the association of Type D traits with 230 (predominantly) lipid metabolites and metabolite ratios.

Methods

Four Dutch cohorts were included, comprising 10,834 individuals. Type D personality traits were measured by self-report questionnaires. A proton nuclear magnetic resonance (NMR) metabolomics platform provided 149 absolute measures (98 belonging to lipoprotein subclasses) and 81 derived ratios. For all, linear regression analyses were performed within each cohort, followed by random-effects meta-analyses. A per-measure FDR q-value<0.05 was set as a study-wise significant association.

Results

SI was significantly associated with a lower omega-3 fatty acids to total fatty acids (FAw3.FA%) ratio, and a lower free cholesterol to total lipids ratio in very small VLDL (XS.VLDL.FC%). FAw3.FA% was also associated to NA (no study-wise significance though). NA showed a suggestive replication (p-value<.05) of the previous reported associations with depression for 5 out of 18 metabolites from the same metabolomics platform: triglycerides in HDL, serum total triglycerides, VLDL cholesterol, mean diameter for VLDL particles and VLDL triglycerides.

Conclusions

In this large meta-analysis, SI was associated with omega-3 fatty acids to total fatty acids ratio, which is suggestive of lower omega-3 fatty acid intake. Only some metabolite biomarkers showed tentative links to Type D and NA. In sum, it seems that there are no major alterations in lipid metabolism associated with Type D traits.

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.