EEG aperiodic dynamics from early through late childhood: Associations with ADHD, cognition, and development

Background

Aperiodic resting electroencephalography (EEG) activity is dynamic, reflecting shifting excitatory:inhibitory (E:I) balance with changing environmental conditions. We examined developmental and cognitive correlates of aperiodic and dynamic aperiodic indices in a cross-sequential cohort of early, middle, and late childhood youth with and without attention deficit hyperactivity disorder (ADHD).

Methods

Two-hundred eighty-five children ages 2 – 14 years provided resting EEG during high- and low-visual input conditions. Licensed clinical psychologists determined ADHD diagnosis or likelihood (in young children). Linear regressions were estimated to examine associations between aperiodic features and age, ADHD diagnosis, IQ, and experimental condition.

Results

From early to middle childhood, the aperiodic exponent increased linearly, indicating lower E:I, followed by a decreasing trajectory in late childhood. The aperiodic exponent was greater with high versus low visual input in young children, but this effect reversed with age. The ADHD group had a decreased aperiodic exponent, overall. Dynamic aperiodic activity, i.e. shifts in E:I balance, was associated with IQ.

Conclusions

The aperiodic exponent and aperiodic dynamics are proxies for age-related cortical maturation and E:I balance, and have distinct associations with ADHD symptoms and cognitive ability.

Significance

We provide novel evidence that dynamic aperiodic activity is a candidate marker of cortical efficiency in childhood.