Jingpi Gao, Ming Liu, Li Wu, Zhiyuan Tian*, Jian-Hong Tang* and Yujie Sun*,
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Activatable Two-Photon-Excited Molecular Fluorescent Probes for Near-Infrared Biosensing and Bioimaging
Two-photon-excited fluorescence imaging (TPEFI) is a rapidly advancing technique for detecting analytes and visualizing biological conditions in real time. Compared to conventional one-photon excitation, TPEFI offers advantages, such as deeper tissue penetration, reduced photodamage, high sensitivity, and superior temporal resolution, making it highly suitable for in vivo imaging applications. The integration of biostimuli-responsive elements into two-photon fluorophores has enabled the development of bioactivatable two-photon-excited small molecules that are effective in near-infrared bioimaging for monitoring diverse biological processes and diseases. This review highlights recent progress (2019–2024) in the design and application of two-photon-excited near-infrared fluorescent probes specifically developed for activity-based bioimaging. We provide a succinct overview of both chemically and enzymatically activated probes by discussing their structural design principles, bioresponsive characteristics, two-photon absorption and emission properties, and their use in vitro and in vivo for monitoring specific biomedical conditions and diseases.
期刊介绍：
ACS Applied Engineering Materials is an international and interdisciplinary forum devoted to original research covering all aspects of engineered materials complementing the ACS Applied Materials portfolio. Papers that describe theory simulation modeling or machine learning assisted design of materials and that provide new insights into engineering applications are welcomed. The journal also considers experimental research that includes novel methods of preparing characterizing and evaluating new materials designed for timely applications. With its focus on innovative applications ACS Applied Engineering Materials also complements and expands the scope of existing ACS publications that focus on materials science discovery including Biomacromolecules Chemistry of Materials Crystal Growth & Design Industrial & Engineering Chemistry Research Inorganic Chemistry Langmuir and Macromolecules.The scope of ACS Applied Engineering Materials includes high quality research of an applied nature that integrates knowledge in materials science engineering physics mechanics and chemistry.
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