评估巴西土著青少年对 BNT162B2 COVID-19 疫苗的免疫反应。

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2024-11-20 DOI:10.1016/j.vaccine.2024.126494

Laís Albuquerque de Oliveira , Isa Rita Brito de Morais , Silvana Beutinger Marchioro , Gabriel Barroso de Almeida , Gleyce Hllen de Almeida de Souza , Tiago da Silva Ferreira , Regina Rossoni , Dyjaene de Oliveira Barbosa , Vinicius João Navarini , Julio Croda , Alex José Leite Torres , Simone Simionatto

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引用次数: 0

摘要

背景：为未成年人接种COVID-19疫苗对全球大流行病控制至关重要，尤其是在土著居民中，由于医疗资源有限和社区生活环境，他们往往更容易受到感染：评估巴西土著青少年接种 BNT162b2 疫苗后的免疫原性反应：对居住在巴西最大的城市周边土著地区的 12 至 18 岁土著青少年进行了一项队列研究。对完成疫苗接种计划之前（D1）和之后（D2）的 SARS-CoV-2 特异性免疫反应进行了分析。通过问卷调查收集了人口统计学数据：在受邀的 129 名青少年中，98 人（75.96%）参加了研究。他们大多是瓜拉尼族，单身，收入较低，只受过小学教育。接种疫苗后，IgG 浓度有明显增加（从 24.03% 增加到 37.02%）。B 淋巴细胞（11.88 至 13.92 个细胞/立方毫米）、记忆 B 细胞（13.58 至 15.96 个细胞/立方毫米）、NK 细胞（20.23 至 24.08 个细胞/立方毫米）和非典型单核细胞（9.23 至 11.34 个细胞/立方毫米）均有所增加，而 CD8+ T 细胞则有所减少（24.41 至 21.69 个细胞/立方毫米）。曾接触过病毒的青少年的 B 淋巴细胞和 CD8+ T 细胞水平有所增加。其他细胞亚群没有因接触病毒而发生明显变化：结论：在接种疫苗的青少年中观察到了抗体水平和某些细胞亚群的升高，证实了 BNT162b2 疫苗在维持体液和细胞反应方面的有效性。这项研究首次描述了使用 BNT162b2 疫苗接种 COVID-19 的土著未成年人的数据，强调了疫苗接种工作的重要性和加强剂量的潜在需求。

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Assessment of the BNT162B2 COVID-19 vaccine immune response in Brazilian indigenous adolescents

Background

COVID-19 vaccination of minors is crucial for global pandemic control, especially among indigenous populations, who are often more vulnerable due to limited healthcare resources and communal living settings.

Objectives

To assess the immunogenicity responses of the BNT162b2 vaccine in immunized Brazilian indigenous adolescents.

Methods

A cohort study was conducted with indigenous adolescents aged 12 to 18 years residing in the largest peri-urban indigenous region in Brazil. SARS-CoV-2-specific immune responses were analyzed before (D1) and after (D2) completion of the vaccination schedule. Demographic data were collected using a questionnaire.

Results

Of the 129 adolescents invited, 98 (75.96 %) participated in the study. Most were of Guarani ethnicity, single, had lower incomes, and were educated only to the elementary level. Post-vaccination, a statistically significant increase was noted in IgG concentration (24.03 % to 37.02 %). Increases were observed in B lymphocytes (11.88 to 13.92 cells/mm³), memory B cells (13.58 to 15.96 cells/mm³), NK cells (20.23 to 24.08 cells/mm³), and non-classical monocytes (9.23 to 11.34 cells/mm³), while CD8+ T cells decreased (24.41 to 21.69 cells/mm³). Adolescents with prior exposure to the virus showed increased levels of B lymphocytes and CD8+ T cells. No significant changes were observed in other cell subpopulations from exposure to the virus.

Conclusion

Elevated levels of antibodies and certain cell subpopulations were observed in vaccinated adolescents, confirming the effectiveness of the BNT162b2 vaccine in maintaining humoral and cellular responses. This study is the first to describe data from indigenous minors vaccinated against COVID-19 with the BNT162b2 vaccine, highlighting the importance of vaccination efforts and the potential need for booster doses.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.