Jakob Rempe, Björn E. Rosengren, Lars Jehpsson, Per Swärd, Magnus Dencker, Magnus K. Karlsson
{"title":"血清骨转换标志物与青春前期晚期和青春期早期的骨量有关。","authors":"Jakob Rempe, Björn E. Rosengren, Lars Jehpsson, Per Swärd, Magnus Dencker, Magnus K. Karlsson","doi":"10.1111/apa.17510","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>To analyse the association between bone turnover markers and bone mass in children and young adults.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This descriptive study followed 132 children (68 boys/64 girls) from Malmö, Sweden, as controls in a school-based intervention study (2000–2017). Height, weight, Tanner stage and bone mass were measured annually from ages 8 to 15 years, with follow-ups at 19 and 23 years of age. Serum markers for bone formation (bone-specific alkaline phosphatase (bALP), N-terminal propeptide of collagen type 1 (PINP), osteocalcin) and resorption (C-terminal telopeptide crosslinks (CTX), tartrate-resistant acid phosphatase (TRAcP 5b)) were collected at ages 9.9 ± 0.6 (mean ± SD) (<i>n</i> = 78), 12.0 ± 0.6 (<i>n</i> = 64), 14.9 ± 0.8 (<i>n</i> = 52), 18.8 ± 0.3 (<i>n</i> = 34) and 23.3 ± 0.6 years (<i>n</i> = 56).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Compared to girls, boys showed higher bone turnover markers at ages 15, 19 and 23 years (all <i>p</i> < 0.05). At 10 years of age (Tanner stage 1 and 2), bALP and TRAcP 5b correlated with current bone mass (adjusted for age and sex), while bALP, PINP, osteocalcin and CTX correlated with bone mass change over the next 2 years (adjusted for age, sex and interval) (all <i>p</i> < 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Bone turnover markers in early Tanner stages predicted both current bone mass and subsequent bone mass changes.</p>\n </section>\n </div>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":"114 5","pages":"944-953"},"PeriodicalIF":2.4000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apa.17510","citationCount":"0","resultStr":"{\"title\":\"Serum bone turnover markers were associated with bone mass in late prepuberty and early puberty\",\"authors\":\"Jakob Rempe, Björn E. Rosengren, Lars Jehpsson, Per Swärd, Magnus Dencker, Magnus K. Karlsson\",\"doi\":\"10.1111/apa.17510\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>To analyse the association between bone turnover markers and bone mass in children and young adults.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This descriptive study followed 132 children (68 boys/64 girls) from Malmö, Sweden, as controls in a school-based intervention study (2000–2017). Height, weight, Tanner stage and bone mass were measured annually from ages 8 to 15 years, with follow-ups at 19 and 23 years of age. Serum markers for bone formation (bone-specific alkaline phosphatase (bALP), N-terminal propeptide of collagen type 1 (PINP), osteocalcin) and resorption (C-terminal telopeptide crosslinks (CTX), tartrate-resistant acid phosphatase (TRAcP 5b)) were collected at ages 9.9 ± 0.6 (mean ± SD) (<i>n</i> = 78), 12.0 ± 0.6 (<i>n</i> = 64), 14.9 ± 0.8 (<i>n</i> = 52), 18.8 ± 0.3 (<i>n</i> = 34) and 23.3 ± 0.6 years (<i>n</i> = 56).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Compared to girls, boys showed higher bone turnover markers at ages 15, 19 and 23 years (all <i>p</i> < 0.05). At 10 years of age (Tanner stage 1 and 2), bALP and TRAcP 5b correlated with current bone mass (adjusted for age and sex), while bALP, PINP, osteocalcin and CTX correlated with bone mass change over the next 2 years (adjusted for age, sex and interval) (all <i>p</i> < 0.05).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Bone turnover markers in early Tanner stages predicted both current bone mass and subsequent bone mass changes.</p>\\n </section>\\n </div>\",\"PeriodicalId\":55562,\"journal\":{\"name\":\"Acta Paediatrica\",\"volume\":\"114 5\",\"pages\":\"944-953\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-11-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apa.17510\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Paediatrica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/apa.17510\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Paediatrica","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/apa.17510","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
Serum bone turnover markers were associated with bone mass in late prepuberty and early puberty
Aim
To analyse the association between bone turnover markers and bone mass in children and young adults.
Methods
This descriptive study followed 132 children (68 boys/64 girls) from Malmö, Sweden, as controls in a school-based intervention study (2000–2017). Height, weight, Tanner stage and bone mass were measured annually from ages 8 to 15 years, with follow-ups at 19 and 23 years of age. Serum markers for bone formation (bone-specific alkaline phosphatase (bALP), N-terminal propeptide of collagen type 1 (PINP), osteocalcin) and resorption (C-terminal telopeptide crosslinks (CTX), tartrate-resistant acid phosphatase (TRAcP 5b)) were collected at ages 9.9 ± 0.6 (mean ± SD) (n = 78), 12.0 ± 0.6 (n = 64), 14.9 ± 0.8 (n = 52), 18.8 ± 0.3 (n = 34) and 23.3 ± 0.6 years (n = 56).
Results
Compared to girls, boys showed higher bone turnover markers at ages 15, 19 and 23 years (all p < 0.05). At 10 years of age (Tanner stage 1 and 2), bALP and TRAcP 5b correlated with current bone mass (adjusted for age and sex), while bALP, PINP, osteocalcin and CTX correlated with bone mass change over the next 2 years (adjusted for age, sex and interval) (all p < 0.05).
Conclusion
Bone turnover markers in early Tanner stages predicted both current bone mass and subsequent bone mass changes.
期刊介绍:
Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including:
neonatal medicine
developmental medicine
adolescent medicine
child health and environment
psychosomatic pediatrics
child health in developing countries