血清骨转换标志物与青春前期晚期和青春期早期的骨量有关。

IF 2.4 4区 医学 Q1 PEDIATRICS
Acta Paediatrica Pub Date : 2024-11-21 DOI:10.1111/apa.17510
Jakob Rempe, Björn E. Rosengren, Lars Jehpsson, Per Swärd, Magnus Dencker, Magnus K. Karlsson
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引用次数: 0

摘要

目的:分析儿童和青少年骨转换标志物与骨量之间的关系:这项描述性研究对瑞典马尔默市的 132 名儿童(68 名男孩/64 名女孩)进行了跟踪调查,他们是一项基于学校的干预研究(2000-2017 年)的对照组。从 8 岁到 15 岁,每年测量一次身高、体重、坦纳期和骨量,并在 19 岁和 23 岁时进行随访。在 9 岁时收集骨形成(骨特异性碱性磷酸酶 (bALP)、1 型胶原蛋白的 N 端前肽 (PINP)、骨钙素)和骨吸收(C 端端肽交联 (CTX)、抗酒石酸磷酸酶 (TRAcP 5b))的血清标记物。结果显示:与女孩相比,男孩的骨质疏松症发生率更高:结果:与女孩相比,男孩在 15、19 和 23 岁时的骨转换标志物较高(均为 p):坦纳早期阶段的骨转换标志物可预测当前的骨量和随后的骨量变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum bone turnover markers were associated with bone mass in late prepuberty and early puberty

Aim

To analyse the association between bone turnover markers and bone mass in children and young adults.

Methods

This descriptive study followed 132 children (68 boys/64 girls) from Malmö, Sweden, as controls in a school-based intervention study (2000–2017). Height, weight, Tanner stage and bone mass were measured annually from ages 8 to 15 years, with follow-ups at 19 and 23 years of age. Serum markers for bone formation (bone-specific alkaline phosphatase (bALP), N-terminal propeptide of collagen type 1 (PINP), osteocalcin) and resorption (C-terminal telopeptide crosslinks (CTX), tartrate-resistant acid phosphatase (TRAcP 5b)) were collected at ages 9.9 ± 0.6 (mean ± SD) (n = 78), 12.0 ± 0.6 (n = 64), 14.9 ± 0.8 (n = 52), 18.8 ± 0.3 (n = 34) and 23.3 ± 0.6 years (n = 56).

Results

Compared to girls, boys showed higher bone turnover markers at ages 15, 19 and 23 years (all p < 0.05). At 10 years of age (Tanner stage 1 and 2), bALP and TRAcP 5b correlated with current bone mass (adjusted for age and sex), while bALP, PINP, osteocalcin and CTX correlated with bone mass change over the next 2 years (adjusted for age, sex and interval) (all p < 0.05).

Conclusion

Bone turnover markers in early Tanner stages predicted both current bone mass and subsequent bone mass changes.

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来源期刊
Acta Paediatrica
Acta Paediatrica 医学-小儿科
CiteScore
6.50
自引率
5.30%
发文量
384
审稿时长
2-4 weeks
期刊介绍: Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries
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