Tonje Bårdsen, Emma Satrell, Ola Drange Røksund, Merete Røineland Benestad, Karl Ove Hufthammer, Hege Clemm, Ingvild Bruun Mikalsen, Knut Øymar, Thomas Halvorsen, Maria Vollsæter
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We used Welch's <i>t</i>-tests to compare term- with EP-born as a group and split by bronchopulmonary dysplasia (BPD), and regression models to test group/cohort interactions.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>In all EP-born cohorts, <i>z</i>-scores for FEV<sub>1</sub>, FEV<sub>1</sub>/FVC, FEF<sub>25%–75%</sub>, DLCO and KCO were reduced compared with term-born. For the 82–85, 91–92 and 99–00 cohorts, deficits for z-FEV<sub>1</sub> and z-DLCO were 1.23 and 0.53; 0.68 and 0.92; and 0.51 and 0.57, respectively (<i>p</i> ≤0.01 for all). Cohort analyses showed stable lung function across the three cohorts overall, but improvements across cohorts for the BPD subgroups in z-FEV<sub>1</sub>, z-FEV<sub>1</sub>/FVC, and z-FEF<sub>25%–75%</sub>.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Adults born EP across three formative decades of neonatal care had stable lung function overall, with notable improvements in BPD subgroups across cohorts.</p>\n </section>\n </div>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":"114 5","pages":"863-876"},"PeriodicalIF":2.4000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apa.17498","citationCount":"0","resultStr":"{\"title\":\"Lung function outcomes in adults born extremely preterm across three decades of advancing perinatal medicine\",\"authors\":\"Tonje Bårdsen, Emma Satrell, Ola Drange Røksund, Merete Røineland Benestad, Karl Ove Hufthammer, Hege Clemm, Ingvild Bruun Mikalsen, Knut Øymar, Thomas Halvorsen, Maria Vollsæter\",\"doi\":\"10.1111/apa.17498\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>Advances in perinatal medicine from 1980 to 2000 improved survival in extremely preterm (EP) neonates. 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引用次数: 0
摘要
目的：1980 年至 2000 年间，围产医学的发展提高了极早产（EP）新生儿的存活率。这些进展的长期影响仍不清楚，我们旨在调查队列对成人肺功能的潜在影响：方法：1982-85 年、1991-92 年和 1999-2000 年期间出生的妊娠期不足 28 周或出生体重不足 1000 克的三个 18 岁人群队列以及足月对照组接受了肺活量测定、体温测定以及肺弥散能力、支气管扩张剂可逆性和气道高反应性测试。我们使用韦尔奇 t 检验比较了足月儿和 EP 出生儿作为一个组以及按支气管肺发育不良（BPD）划分的组别，并使用回归模型检验了组别/队列间的交互作用：在所有 EP 出生的队列中，FEV1、FEV1/FVC、FEF25%-75%、DLCO 和 KCO 的 z 值均比足月儿降低。在 82-85、91-92 和 99-00 组群中，z-FEV1 和 z-DLCO 分别为 1.23 和 0.53；0.68 和 0.92；0.51 和 0.57（P 均≤0.01）。队列分析显示，三个队列的肺功能总体稳定，但BPD亚组的z-FEV1、z-FEV1/FVC和z-FEF25%-75%在各队列中均有所改善：结论：在新生儿护理的三个成长十年中，EP出生的成年人肺功能总体稳定，而BPD亚组的肺功能在各组群中有明显改善。
Lung function outcomes in adults born extremely preterm across three decades of advancing perinatal medicine
Aim
Advances in perinatal medicine from 1980 to 2000 improved survival in extremely preterm (EP) neonates. Long-term effects of these developments remain unclear, and we aimed to investigate potential cohort effects on adult lung function.
Methods
Three 18-year-old population-based cohorts born at ≤28 weeks gestation or with birthweight ≤1000 g during 1982–85, 1991–92 and 1999–2000 and term-controls underwent spirometry, body plethysmography, and tests of lung diffusing capacity, bronchodilator reversibility, and airway hyperresponsiveness. We used Welch's t-tests to compare term- with EP-born as a group and split by bronchopulmonary dysplasia (BPD), and regression models to test group/cohort interactions.
Results
In all EP-born cohorts, z-scores for FEV1, FEV1/FVC, FEF25%–75%, DLCO and KCO were reduced compared with term-born. For the 82–85, 91–92 and 99–00 cohorts, deficits for z-FEV1 and z-DLCO were 1.23 and 0.53; 0.68 and 0.92; and 0.51 and 0.57, respectively (p ≤0.01 for all). Cohort analyses showed stable lung function across the three cohorts overall, but improvements across cohorts for the BPD subgroups in z-FEV1, z-FEV1/FVC, and z-FEF25%–75%.
Conclusion
Adults born EP across three formative decades of neonatal care had stable lung function overall, with notable improvements in BPD subgroups across cohorts.
期刊介绍：
Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including:
neonatal medicine
developmental medicine
adolescent medicine
child health and environment
psychosomatic pediatrics
child health in developing countries
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