A wearable gait lab powered by sensor-driven digital twins for quantitative biomechanical analysis post-stroke.

Commonly, quantitative gait analysis post-stroke is performed in fully equipped laboratories housing costly technologies for quantitative evaluation of a patient's movement capacity. Combining such technologies with an electromyography (EMG)-driven musculoskeletal model can estimate muscle force properties non-invasively, offering clinicians insights into motor impairment mechanisms. However, lab-constrained areas and time-demanding sensor setup and data processing limit the practicality of these technologies in routine clinical care. We presented wearable technology featuring a multi-channel EMG-sensorized garment and an automated muscle localization technique. This allows unsupervised computation of muscle-specific activations, combined with five inertial measurement units (IMUs) for assessing joint kinematics and kinetics during various walking speeds. Finally, the wearable system was combined with a person-specific EMG-driven musculoskeletal model (referred to as human digital twins), enabling the quantitative assessment of movement capacity at a muscle-tendon level. This human digital twin facilitates the estimation of ankle dorsi-plantar flexion torque resulting from individual muscle-tendon forces. Results demonstrate the wearable technology's capability to extract joint kinematics and kinetics. When combined with EMG signals to drive a musculoskeletal model, it yields reasonable estimates of ankle dorsi-plantar flexion torques (R ² = 0.65 ± 0.21) across different walking speeds for post-stroke individuals. Notably, EMG signals revealing an individual's control strategy compensate for inaccuracies in IMU-derived kinetics and kinematics when input into a musculoskeletal model. Our proposed wearable technology holds promise for estimating muscle kinetics and resulting joint torque in time-limited and space-constrained environments. It represents a crucial step toward translating human movement biomechanics outside of controlled lab environments for effective motor impairment monitoring.