高循环 HMGB1 表明接受化疗免疫疗法的晚期白肌瘤患者预后良好。

IF 6.5 2区医学 Q1 IMMUNOLOGY

Oncoimmunology Pub Date : 2024-12-31 Epub Date: 2024-11-21 DOI:10.1080/2162402X.2024.2432059

Lucillia Bezu, Guido Kroemer

引用次数: 0

摘要

很少有临床研究调查免疫原性细胞死亡（ICD）的激活与肿瘤预后之间的潜在联系。最近发表的一项 1b 期试验数据表明，在接受多柔比星、达卡巴嗪和尼韦鲁单抗联合治疗的晚期白肌瘤患者中，与 ICD 相关的血浆高迁移率组框 1（HMGB1）浓度激增预示着良好的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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High circulating HMGB1 indicates good prognosis in patients with advanced leiomyosarcoma under chemoimmunotherapy.

Few clinical studies investigated the putative link between the activation of immunogenic cell death (ICD) and the oncological outcome. Recent data, published in a Phase 1b trial, demonstrated that an ICD-associated surge in the plasma concentration of high-mobility group box 1 (HMGB1) indicates favorable prognosis in patients with advanced leiomyosarcomas treated with the combination of doxorubicin, dacarbazine and nivolumab.

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来源期刊

Oncoimmunology ONCOLOGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

12.50

自引率

2.80%

发文量

276

审稿时长

24 weeks

期刊介绍： OncoImmunology is a dynamic, high-profile, open access journal that comprehensively covers tumor immunology and immunotherapy. As cancer immunotherapy advances, OncoImmunology is committed to publishing top-tier research encompassing all facets of basic and applied tumor immunology. The journal covers a wide range of topics, including: -Basic and translational studies in immunology of both solid and hematological malignancies -Inflammation, innate and acquired immune responses against cancer -Mechanisms of cancer immunoediting and immune evasion -Modern immunotherapies, including immunomodulators, immune checkpoint inhibitors, T-cell, NK-cell, and macrophage engagers, and CAR T cells -Immunological effects of conventional anticancer therapies.