[树突状细胞疫苗和溶瘤腺病毒对结直肠癌的联合疗效]。

Q4 Medicine

Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-10-01

Naohiro Okada, Hiroshi Tazawa, Motohiko Yamada, Kanto Suemori, Satoru Kikuchi, Shinji Kuroda, Kazuhiro Noma, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara

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引用次数: 0

摘要

树突状细胞（DC）疫苗疗法作为一种能有效诱导细胞毒性 T 淋巴细胞的癌症免疫疗法，已被广泛研究。然而，它们在临床实践中的疗效尚未得到证实。我们开发了一种携带肿瘤抑制基因 p53 的溶瘤腺病毒 OBP-702，并证明了其通过 p53 诱导细胞病理效应和激活抗肿瘤免疫的治疗潜力。本研究探讨了 p53 转导的 DC 疫苗和 OBP-702 对结直肠癌的联合作用。

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本刊更多论文

[Combined Efficacy of Dendritic Cell Vaccine and Oncolytic Adenovirus in Colorectal Cancer].

Dendritic cell(DC)vaccine therapy has been widely studied as cancer immunotherapy that potently induces cytotoxic T lymphocytes. However, their efficacy in clinical practice has not yet been established. We have developed an oncolytic adenovirus OBP-702 carrying the tumor suppressor gene p53 and have demonstrated its therapeutic potential to induce cytopathic effect and activate antitumor immunity via p53 induction. In this study, we investigated the combined effect of p53-transduced DC vaccine and OBP-702 in colorectal cancer.

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来源期刊

Japanese Journal of Cancer and Chemotherapy Medicine-Medicine (all)

CiteScore

0.20

自引率

0.00%

发文量

337