与小细胞肺癌相关的副肿瘤性神经肌肉疾病的困难鉴别诊断：两个病例的报告

Q3 Medicine

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2024-12-20

Kohei Umemoto, Katsuyoshi Tomomatsu, Mika Urata, Eriko Okazaki, Kai Yamazaki, Tomohiro Yoshikawa, Naoki Okada, Shigeaki Hattori, Tomoe Takeuchi, Yukihiro Horio, Hiroto Takiguchi, Kyoko Niimi, Naoki Hayama, Yoko Ito, Ryoko Imazeki, Tsuyoshi Oguma, Eiichiro Nagata, Koichiro Asano

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引用次数: 0

摘要

兰伯特-伊顿肌萎缩综合征（LEMS）是小细胞肺癌（SCLC）并发的一种副肿瘤性神经综合征。LEMS的临床症状与重症肌无力（MG）重叠，容易导致误诊。在此，我们报告了两例伴有LEMS样疾病的SCLC患者，由于在高频刺激下肌电图结果不典型且无蜡样，因此很难与MG相鉴别。这两名患者对口服吡啶斯的明和静脉注射免疫球蛋白的反应都很差，据报道，他们的抗P/Q型电压门控钙通道抗体呈阳性，这是LEMS的特征。根据临床症状和肌电图检查结果来区分 LEMS 和 MG 是很困难的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Difficult Differential Diagnosis of Paraneoplastic Neuromuscular Diseases Associated with Small Cell lung Cancer: A Report of Two Cases.

Lambert-Eaton myasthenic syndrome (LEMS) is a paraneoplastic neurological syndrome complication of small cell lung cancer (SCLC). The clinical symptoms of LEMS overlap with those of myasthenia gravis (MG), leading to misdiagnosis. Herein, we report two cases of SCLC with LEMS-like disease that were difficult to distinguish from MG because of atypical electromyographic findings without waxing patterns on high-frequency stimulation. Both patients responded poorly to oral pyridostigmine and intravenous immunoglobulin, and were reported to be positive for the anti-P/Q-type voltage-gated calcium channel antibody characteristic of LEMS. Differentiating between LEMS and MG based on clinical symptoms and EMG findings can be difficult.

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来源期刊

Tokai Journal of Experimental and Clinical Medicine Medicine-Medicine (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： The Tokai Journal of Experimental and Clinical Medicine, also referred to as Tokai Journal, is an official quarterly publication of the Tokai Medical Association. Tokai Journal publishes original articles that deal with issues of clinical, experimental, socioeconomic, cultural and/or historical importance to medical science and related fields. Manuscripts may be submitted as full-length Original Articles or Brief Communications. Tokai Journal also publishes reviews and symposium proceedings. Articles accepted for publication in Tokai Journal cannot be reproduced elsewhere without written permission from the Tokai Medical Association. In addition, Tokai Journal will not be held responsible for the opinions of the authors expressed in the published articles.