内膜干扰抗疟药物的多组学研究。

IF 7 1区医学 Q1 PARASITOLOGY

Trends in parasitology Pub Date : 2024-11-20 DOI:10.1016/j.pt.2024.11.002

Sophie L Collier, Stuart A Ralph

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引用次数: 0

摘要

将天然产品用作抗疟药物所面临的挑战包括其隐秘的作用机制（进而产生抗药性），以及在没有丰富天然来源的情况下进行复杂而昂贵的合成。最近，Chahine 等人以异氰基橙皮烯的卡利桧醇家族为例，提出了应对这些挑战的可行方法。

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Multiomic interrogation of an endomembrane disrupting antimalarial.

Challenges in adapting natural products as antimalarials include their cryptic mechanism of action (and by extension resistance), as well as their complex and expensive synthesis without an abundant natural source. Recently, Chahine et al. presented plausible means to address these challenges in the case of the kalihinol family of isocyanoterpenes.

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来源期刊

Trends in parasitology 医学-寄生虫学

CiteScore

14.00

自引率

3.10%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.