间充质干细胞和间充质干细胞衍生的外泌体：治疗女性生殖功能障碍的有吸引力的方法。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biology Reports Pub Date : 2024-11-22 DOI:10.1007/s11033-024-10106-6

Sepideh Hassanpour Khodaei, Shahnaz Sabetkam, Hossein Kalarestaghi, Khadijeh Dizaji Asl, Zeinab Mazloumi, Mohammadmahdi Bahramloo, Nahid Norouzi, Elahe Naderali, Ali Rafat

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引用次数: 0

摘要

不孕不育是男性或女性生殖系统的生殖健康问题。传统的辅助生殖技术（ART）多年来一直无法解决各种不孕不育症。临床研究人员一直在寻求使用比旧方法更有效、更无创的新方法来治疗不孕不育症。最近，间充质干细胞（MSCs）和间充质干细胞衍生的外泌体（MSC-Exos）通过旁分泌活性在治疗各种原因引起的不孕症和改善妊娠结局方面发挥了重要作用。在这篇综述中，我们将重点讨论间充质干细胞和间充质干细胞-外泌体细胞疗法在不同类型女性生殖系统疾病的女性不孕症中的作用。

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Mesenchymal stem cells and mesenchymal stem cell-derived exosomes: attractive therapeutic approaches for female reproductive dysfunction.

Infertility is a reproductive health problem in the male or female reproductive system. Traditional assisted reproductive technology (ART) has been unable to solve various cases of infertility for years. Clinical researchers have sought to treat infertility using new methods that are more effective and noninvasive than the old methods. Recently, Mesenchymal stem cells (MSCs) and MSCs-derived Exosomes (MSC-Exos) via paracrine activity play an important role in treating various causes of infertility and improving pregnancy outcomes. In this review, we focus on the roles of MSCs and MSC-Exos cell therapy in female infertility in the different types of female reproductive disorders.

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来源期刊

Molecular Biology Reports 生物-生化与分子生物学

CiteScore

5.00

自引率

0.00%

发文量

1048

审稿时长

5.6 months

期刊介绍： Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews.