XBB.1.5适应性加强免疫对SARS-CoV-2免疫印记的影响。

IF 6.9 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2024-11-21 DOI:10.1038/s41541-024-01023-7

Jernej Pušnik, Werner O Monzon-Posadas, Emmanuil Osypchuk, Aleksandra Elzbieta Dubiel, Maximilian Baum, Paulina Fehring, Antonia Büning, Tobias Klant, Hendrik Streeck

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引用次数: 0

摘要

在本研究中，Pušnik 等人调查了 XBB.1.5 适应型加强型疫苗是否能克服野生型疫苗对 SARS-CoV-2 免疫力的持续印记。研究结果表明，接种加强型疫苗后，血浆对同源变体的中和作用增强。在 3/20 人中观察到了针对 XBB.1.5 变异体表面蛋白变异表位的新体液反应。加强接种对 T 细胞反应没有明显影响。

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Effect of XBB.1.5-adapted booster vaccination on the imprinting of SARS-CoV-2 immunity.

In the present study, Pušnik et al. investigated whether the XBB.1.5-adapted booster can overcome the persistent imprinting of SARS-CoV-2 immunity by wild-type based vaccines. The findings demonstrate increased plasma neutralization against the homologous variant following the booster vaccination. Formation of de novo humoral response against the mutated epitopes of XBB.1.5 variant's surface proteins was observed in 3/20 individuals. The booster vaccination had no significant effect on T-cell response.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.