寿命早期摄入山梨醇的肠道微生物组和身体组成。

IF 3.2 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Pub Date : 2024-10-24 DOI:10.1016/j.nut.2024.112614

Ying-Yueh Chu Ph.D. , Yu-Chen S.H. Yang Ph.D. , Shih-Yuan Hsu MSc , Hsien-Yu Fan Ph.D. , Liang-Dar Hwang Ph.D. , Jacus S. Nacis Ph.D. , Yang Ching Chen Ph.D.

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引用次数: 0

摘要

研究目的研究方法和步骤：从台北母婴健康中心收集了 369 名孕妇及其婴儿（4 个月至 5 岁）的山梨醇摄入量、体重指数（BMI）和粪便样本：研究方法：研究人员收集了台北市母婴营养队列的 369 名孕妇及其婴儿（4 个月至 5 岁）和台湾青春期纵向研究的 1946 名儿童和青少年（6-18 岁）的山梨醇摄入量、体重指数（BMI）和粪便样本。采用广义线性混合模型比较了山梨醇使用者与山梨醇非使用者的 BMI-z 评分。研究还调查了两个队列中微生物组的贝塔多样性。结果表明，山梨醇摄入量高的儿童和青少年体内的山梨醇含量较低，而山梨醇摄入量低的儿童和青少年体内的山梨醇含量较高：结果：与未摄入山梨醇的儿童和青少年相比，山梨醇摄入量高的儿童和青少年在 6 至 10 岁和 11 至 18 岁时的 BMI-z 评分较低（P < 0.01）。使用山梨醇和不使用山梨醇的人的微生物群β多样性差异显著。与母亲在怀孕期间不使用山梨醇的婴幼儿相比，母亲使用山梨醇的婴幼儿肠道中的双歧杆菌含量更高。有几种微生物参与了肥胖的调节，如葡萄球菌、粪便杆菌和振荡螺旋体_UCG-005与人体测量指标呈负相关：结论：山梨醇的摄入量与儿童和青少年较低的体重指数有关。结论：山梨醇的摄入量与儿童和青少年较低的体重指数有关。山梨醇的摄入量可影响有益微生物群的组成和丰富程度，有助于维持生命早期的理想体重和代谢平衡。

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Gut microbiome and body composition with sorbitol intake during early lifespan

Objective

The association of sorbitol intake with maintaining healthy body weight through the gut microbiome during early life was investigated.

Research Methods and Procedures

Sorbitol intake, body mass index (BMI), and fecal samples were collected in the total of 369 pregnant women with their infants (aged 4 months to 5 years) from the Taipei Mother-Infant Nutrition Cohort and 1946 children and adolescents (aged 6–18 years) from the Taiwan Puberty Longitudinal Study. The BMI-z score in sorbitol users was compared to that in sorbitol nonusers using generalized linear mixed model. The beta diversity of microbiome was investigated in both cohorts. The association between the richness of microbes and body composition was analyzed.

Results

The children and adolescents with high sorbitol intake had lower BMI-z score at 6 to 10 and 11 to 18 years of age (P < 0.01) compared with those without sorbitol intake. The beta diversity of the microbiome differed significantly between the sorbitol users and nonusers. Bifidobacterium was higher in the gut of infants and children whose mothers were sorbitol users than that of infants and children whose mothers were sorbitol nonusers during pregnancy. Several microbes were involved in the regulation of obesity, such as Staphylococcus, Faecalibacterium, and Oscillospiraceae_UCG-005 negatively associated with anthropometric measures.

Conclusions

Sorbitol intake was associated with lower child and adolescent BMI. Sorbitol consumption could shape the composition and richness of beneficial microbiota, contributing to the maintenance of ideal body weight and metabolic homeostasis in early life.

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来源期刊

Nutrition 医学-营养学

CiteScore

7.80

自引率

2.30%

发文量

300

审稿时长

60 days

期刊介绍： Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.