用于心血管风险评估的亚临床甲状腺功能减退症的高敏 C 反应蛋白和血脂组合变化

Q3 Medicine
Smrity Rajkarnikar, Vijay Kumar Sharma, Sujata Baidya, Pratibha Kadel, Eans Tara Tuladhar, Apeksha Niraula, Aseem Bhattarai, Mithileshwer Raut, Raju Kumar Dubey, Naresh Parajuli
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引用次数: 0

摘要

研究背景本研究的目的是调查亚临床甲状腺功能减退症与高敏 C 反应蛋白和血脂谱之间的关系:这项以医院为基础的横断面比较研究为期六个月。共招募了 71 名亚临床甲状腺功能减退症患者和 37 名健康对照组受试者。研究人员测量了甲状腺激素、血脂概况和 hs- CRP,并使用血脂变量计算血脂指数。采用学生 t 检验比较平均值,并采用斯皮尔曼相关性检验确定变量之间的关联。ROC 曲线分析用于确定测试的诊断价值:在 71 例病例和 37 例对照中,女性占大多数(病例占 71.8%,对照占 83.8%)。病例组和对照组的高敏 C 反应蛋白、血浆致动脉粥样硬化指数、脂蛋白综合指数和非高密度脂蛋白胆固醇的平均值均有统计学意义。促甲状腺激素与高敏 C 反应蛋白 r=0.492,p 0.001;血浆致动脉粥样硬化指数与促甲状腺激素 r=0.430,p 0.001;脂蛋白综合指数与促甲状腺激素呈正相关(r=0.269,p =0.005)、促甲状腺激素和非高密度脂蛋白胆固醇(r=0.308,p=0.001)以及致动脉粥样硬化指数和低密度脂蛋白 r=0.712,p 0.001,根据 Spearmans 相关性,两者之间存在统计学意义上的弱相关性。高敏 C 反应蛋白的 ROC 曲线下面积表明,它是心血管风险评估的一个积极生物标志物:我们的研究结果表明,精神分裂症患者罹患心血管疾病的风险更高,而高敏感 C 反应蛋白是一个重要的标志物,因此需要及时干预。即使是血脂正常的患者也必须测定血脂指数和 AIP,以改善动脉粥样硬化风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High Sensitive C-Reactive Protein and Lipid Profile Alteration In Subclinical Hypothyroidism for Cardiovascular Risk Assessment.

Background: The purpose of this study was to investigate the association of subclinical hypothyroidism with High sensitive C-reactive protein and lipid profile which can predispose to development of Cardiovascular disease.

Methods: This hospital-based comparative cross-sectional study was conducted for a period of six months. A total of 71 patients with subclinical hypothyroidism and 37 healthy control subjects were enrolled for the study. Thyroid hormones, lipid profile, hs- CRP were measured and lipid variables were used to calculate lipid indices. Student t-test were used to compare means and Spearmans correlation was done to determine the association between variables. ROC curve analysis was used to determine the diagnostic value of tests.

Results: Out of 71 cases and 37 control, majority had female preponderance (71.8% in case and 83.8% in control). The mean values between case and control groups for High sensitive C-Reactive Protein, Atherogenic index of plasma, Lipoprotein combined index and non-High Density Lipoprotein cholesterol were statistically significant. There was positive correlation between Thyroid Stimulating Hormone and High sensitive C-Reactive Protein r=0.492, p 0.001, Atherogenic index of plasma and Thyroid Stimulating Hormone r=0.430, p 0.001, Lipoprotein combined index and Thyroid Stimulating Hormone (r=0.269, p =0.005), Thyroid Stimulating Hormone and non-High Density Lipoprotein cholesterol (r=0.308, p=0.001) and Atherogenic Index and Low Density Lipoprotein r= 0.712, p 0.001 with weak correlation with statistical significance as per Spearmans correlation. Area under ROC curve for High sensitive C-Reactive Protein indicated it as a positive biomarker for cardiovascular risk assessment.

Conclusions: Our findings shows that sch patients are more at risk of cvd and hs-crp contributes as a significant marker, thus requiring timely intervention. Lipid indices and AIP must be determined even in patients with a normal lipid profile to improve atherogenic risk.

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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
81
审稿时长
15 weeks
期刊介绍: The journal publishes articles related to researches done in the field of biomedical sciences related to all the discipline of the medical sciences, medical education, public health, health care management, including ethical and social issues pertaining to health. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed original research papers, case reports, systematic reviews and meta-analysis. Editorial, Guest Editorial, Viewpoint and letter to the editor are solicited by the editorial board. Frequently Asked Questions (FAQ) regarding manuscript submission and processing at JNHRC.
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