斑马鱼与铁和铝的慢性接触:评估行为、组织病理学和遗传毒性变化的逆转和世代交替。

IF 4.4 3区 医学 Q2 ENVIRONMENTAL SCIENCES
Gabriela Zimmermann Prado Rodrigues, Mariana Finkler, Thainá Garbino Dos Santos, Juliana Machado Kayser, Diego Del Duca Lima, Jorge Henrique Burghausen, Diogo Losch de Oliveira, Ana Luiza Ziulkoski, Günther Gehlen
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引用次数: 0

摘要

本研究旨在报告斑马鱼长期暴露于环境相关浓度为 0.5、2.4 和 5.0 mg L-1 的铁(Fe)和 0.2、0.4 和 2.0 mg L-1 的铝(Al)所产生的影响。我们还评估了该物种可能发生的组织病理学、行为学和遗传毒性变化的逆转和代际转移(F1)。运动变化可能是由凋亡细胞数量和端脑线粒体活性的增加引起的,尤其是在接触铝 30 天后,并且在恢复后(30 天)仍持续存在。我们还观察到组织病理学的变化,如肠小管细胞数量的增加,甚至在这些动物的恢复期之后也是如此。我们的结果还表明,所使用的铁浓度不足以导致遗传毒性、行为和肠上皮细胞变化。接触过铝的动物的成年后代(F1)在运动和上皮细胞数量方面都出现了变化,这表明即使这种污染物的浓度很低,也会对水生生物群的后代造成危害。一般来说,动物对铁的耐受性较强,这可能与机体对这种金属的生理需求有关。尽管如此,所有导致物种发生变化的两种金属浓度都是巴西环境或巴西法律规定的。这凸显了更新指导方针和持续监测水生环境的必要性,因为即使在假设的环境净化情况下,一些变化也可能持续存在并影响不同的营养级。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chronic Exposure of Zebrafish to Iron and Aluminum: Evaluation of Reversal and Generational Transposition of Behavioral, Histopathological, and Genotoxic Changes.

This study aimed to report the effects of chronic exposure of zebrafish exposed to environmentally relevant concentrations of 0.5, 2.4, and 5.0 mg L-1 iron (Fe) and 0.2, 0.4, and 2.0 mg L-1 aluminum (Al). We also evaluated the reversal and generational transposition (F1) of possible histopathological, behavioral, and genotoxic changes in the species. Locomotion changes that may have been caused by the increase in the number of apoptotic cells and in the telencephalic mitochondrial activity were observed especially after the 30 days exposure to Al and persisted after recovery (30 days). We also observed histopathological changes, such as an increase in the number of intestinal goblet cells, even after the recovery period in these animals. Our results also showed that the Fe concentrations used were insufficient to cause genotoxicity, behavioral and intestinal epithelium changes. The adult offspring (F1) of animals exposed to Al showed changes in locomotion and in the amount of goblet cells, demonstrating that even in low concentrations this pollutant can harm subsequent generations in the aquatic biota. Animals demonstrate, in general, greater tolerance to Fe which may be related to the physiological demand of this metal by the body. Even so, all concentrations of both metals that caused some change in the species represent Brazilian environmental occurrences or Brazilian legislation. It highlights the need for updating the guidelines and constant monitoring of aquatic environments, since even in the face of a hypothetical decontamination of the environment, some changes could persist and affect different trophic levels.

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来源期刊
Environmental Toxicology
Environmental Toxicology 环境科学-毒理学
CiteScore
7.10
自引率
8.90%
发文量
261
审稿时长
4.5 months
期刊介绍: The journal publishes in the areas of toxicity and toxicology of environmental pollutants in air, dust, sediment, soil and water, and natural toxins in the environment.Of particular interest are: Toxic or biologically disruptive impacts of anthropogenic chemicals such as pharmaceuticals, industrial organics, agricultural chemicals, and by-products such as chlorinated compounds from water disinfection and waste incineration; Natural toxins and their impacts; Biotransformation and metabolism of toxigenic compounds, food chains for toxin accumulation or biodegradation; Assays of toxicity, endocrine disruption, mutagenicity, carcinogenicity, ecosystem impact and health hazard; Environmental and public health risk assessment, environmental guidelines, environmental policy for toxicants.
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