ANPEP 基因的多态性与 2 型糖尿病的微血管并发症有关。

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI:10.1007/s10517-024-06286-7

Ya E Korvyakova, I E Azarova, D D Markina, M I Churilin, O Yu Bushueva, E Yu Klyosova, M A Solodilova, A V Polonikov

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引用次数: 0

摘要

我们研究了氨肽酶 N 基因（ANPEP）多态性与 2 型糖尿病（T2DM）患者糖尿病视网膜病变和肾病发生的关系。利用 MassARRAY 系统对 T2DM 患者（1425 人）的 DNA 样本进行了 23 个单核苷酸多态性（SNPs）的基因分型。结果发现，T2DM 患者中 ANPEP 基因的 SNP rs13380049 与较低的糖尿病视网膜病变（OR=0.54，95%CI 0.36-0.82，p=0.0032）和肾病（OR=0.66，95%CI 0.44-0.99，p=0.048）风险有关。此外，SNP rs25653 与视网膜病变相关，多态性 rs6496608、rs72756574、rs9920421 和 rs4932143 与糖尿病肾病相关。该研究表明，ANPEP基因多态性在确定T2DM患者微血管并发症方面起着重要作用。

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Polymorphisms of ANPEP Gene Are Associated with Microvascular Complications of Type 2 Diabetes.

We studied the association of polymorphisms in the aminopeptidase N gene (ANPEP) with the development of diabetic retinopathy and nephropathy in patients with type 2 diabetes mellitus (T2DM). DNA samples from T2DM patients (n=1425) were genotyped for 23 single nucleotide polymorphisms (SNPs) using the MassARRAY system. Associations of SNP rs13380049 of the ANPEP gene with a lower risk of diabetic retinopathy (OR=0.54, 95%CI 0.36-0.82, p=0.0032) and nephropathy (OR=0.66, 95%CI 0.44-0.99, p=0.048) were found in T2DM patients. In addition, SNP rs25653 was associated with retinopathy, and polymorphisms rs6496608, rs72756574, rs9920421, and rs4932143 were associated with diabetic nephropathy. The study demonstrated the contribution of ANPEP gene polymorphisms in the determination of microvascular complications in T2DM patients.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.