额叶皮层中主观价值的特定模式表征和一般模式表征。

IF 5.2 1区 生物学 Q1 BIOLOGY
Shilpa Dang, Jessica Emily Antono, Igor Kagan, Arezoo Pooresmaeili
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引用次数: 0

摘要

神经经济学理论认为,与不同奖励或奖励预测刺激相关的价值是按照一个共同的参考尺度编码的,与它们的感官特性无关。然而,在刺激-奖赏配对不断变化的动态环境中,大脑还必须代表奖赏刺激的感官特征。大脑是如何平衡这些需求的--既要为估价提供共同的参考尺度,又要保持对感官环境的敏感性--目前尚不清楚。为了研究这个问题,我们对参与动态觅食任务的人类参与者进行了一项 fMRI 研究,这项任务要求整合听觉或视觉选择选项的奖励历史,并更新每种感官模式的主观价值。单变量 fMRI 分析显示,眶额叶皮层(OFC)中存在特定模式的价值表征,而腹侧前额叶皮层(vmPFC)中存在一般模式的价值表征,这一点得到了探索性多变量模式分类方法的证实。重要的是,当任务涉及基于指令而非基于价值的选择时,不存在特定模态的价值表征。有效连接分析表明,特定模式的价值表征来自于听觉和视觉感觉皮层、相应的 OFC 簇以及 vmPFC 之间的选择性双向互动。这些结果说明了大脑是如何实现对奖赏刺激的感官环境敏感的估价过程的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Modality-specific and modality-general representations of subjective value in frontal cortex

Modality-specific and modality-general representations of subjective value in frontal cortex
Neuroeconomics theories propose that the value associated with diverse rewards or reward-predicting stimuli is encoded along a common reference scale, irrespective of their sensory properties. However, in a dynamic environment with changing stimulus-reward pairings, the brain must also represent the sensory features of rewarding stimuli. The mechanism by which the brain balances these needs—deriving a common reference scale for valuation while maintaining sensitivity to sensory contexts—remains unclear. To investigate this, we conducted an fMRI study with human participants engaged in a dynamic foraging task, which required integrating the reward history of auditory or visual choice options and updating the subjective value for each sensory modality. Univariate fMRI analysis revealed modality-specific value representations in the orbitofrontal cortex (OFC) and modality-general value representations in the ventromedial prefrontal cortex (vmPFC), confirmed by an exploratory multivariate pattern classification approach. Crucially, modality-specific value representations were absent when the task involved instruction-based rather than value-based choices. Effective connectivity analysis showed that modality-specific value representations emerged from selective bidirectional interactions across the auditory and visual sensory cortices, the corresponding OFC clusters, and the vmPFC. These results illustrate how the brain enables a valuation process that is sensitive to the sensory context of rewarding stimuli. Model-based fMRI study shows how context-sensitive valuation arises from modality-specific and general reward value coding in the orbitofrontal cortex (OFC) and ventromedial prefrontal cortex (vmPFC), through dynamic interactions with sensory cortices.
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来源期刊
Communications Biology
Communications Biology Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
1.70%
发文量
1233
审稿时长
13 weeks
期刊介绍: Communications Biology is an open access journal from Nature Research publishing high-quality research, reviews and commentary in all areas of the biological sciences. Research papers published by the journal represent significant advances bringing new biological insight to a specialized area of research.
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