脑外伤后中风的风险:系统回顾与荟萃分析。

IF 2 4区 医学 Q3 CLINICAL NEUROLOGY
Armin Karamian, Hana Farzaneh, Masoud Khoshnoodi, Najmeh Hosseini, Mojtaba Taheri, Brandon Lucke-Wold
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引用次数: 0

摘要

背景:在美国,创伤性脑损伤(TBI)是导致死亡和残疾的主要原因。有人认为创伤性脑损伤与中风之间存在关联,这强调了加强创伤后医疗监测的必要性。我们进行了一项系统性回顾和荟萃分析,以研究既往 TBI 与未来诊断任何类型中风之间的联系:方法:我们在 PubMed、Google Scholar 和 Cochrane Library 上进行了全面搜索,以找到符合条件的研究,调查创伤后脑损伤与中风长期风险之间的关系:结果:在 2378 项研究中,有 11 篇文章符合荟萃分析的纳入标准。汇总分析表明,与对照组患者相比,有创伤性脑损伤病史的患者中风风险更高(随机效应 HR = 1.59,95% CI 1.37-1.85,p 2 = 97%)。创伤性脑损伤患者发生缺血性脑卒中的风险高于非创伤性脑损伤患者(随机效应 HR = 1.52,95% CI 1.36-1.70,P 2 = 93%)。此外,创伤性脑损伤与出血性脑卒中之间存在很强的相关性(随机效应 HR = 4.68,95% CI 2.93-7.49,P 2 = 93%):我们的研究结果表明,无论中风类型如何,创伤性脑损伤与中风的长期风险之间都存在关系。结论:我们的研究结果表明,创伤性脑损伤与中风的长期风险之间存在关系,而与中风的类型无关。中风风险在受伤后的头几个月升高,并在创伤后的数年内持续走高。与轻度创伤性脑损伤患者相比,中重度创伤性脑损伤患者发生创伤性脑损伤后中风的风险更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk of stroke after traumatic brain injury: a systematic review and meta-analysis.

Background: Traumatic brain injury (TBI) is a major cause of death and disability in the United States. There is a suggested association between TBI and stroke, emphasizing the need for increased medical monitoring post-trauma. We conducted a systematic review and meta-analysis to investigate the link between previous TBI and the future diagnosis of any type of stroke.

Methods: A comprehensive search was conducted on PubMed, Google Scholar, and Cochrane Library to find eligible studies investigating the association between TBI and long-term risk of stroke.

Results: Out of 2,378 studies, 11 articles met the inclusion criteria for our meta-analysis. The pooled analysis showed that the patients who had a history of TBI were at greater risk for stroke than patients in the control group (random-effect HR = 1.59, 95% CI 1.37-1.85, p < 0.001, I2 = 97%). The risk of ischemic stroke in TBI patients was greater than in non-TBI patients (random-effect HR = 1.52, 95% CI 1.36-1.70, p < 0.001, I2 = 93%). Additionally, there is a strong correlation between TBI and hemorrhagic stroke (random-effect HR = 4.68, 95% CI 2.93-7.49, p < 0.001, I2 = 93%).

Conclusion: Our results indicate that there is a relationship between TBI and long-term risk of stroke, regardless of the stroke type. The risk is elevated in the first months post-injury and continues to be high in the years following the trauma. Individuals with moderate to severe TBI face a higher risk of developing a post-TBI stroke than those with mild TBI.

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来源期刊
Acta neurologica Belgica
Acta neurologica Belgica 医学-临床神经学
CiteScore
4.20
自引率
3.70%
发文量
300
审稿时长
6-12 weeks
期刊介绍: Peer-reviewed and published quarterly, Acta Neurologica Belgicapresents original articles in the clinical and basic neurosciences, and also reports the proceedings and the abstracts of the scientific meetings of the different partner societies. The contents include commentaries, editorials, review articles, case reports, neuro-images of interest, book reviews and letters to the editor. Acta Neurologica Belgica is the official journal of the following national societies: Belgian Neurological Society Belgian Society for Neuroscience Belgian Society of Clinical Neurophysiology Belgian Pediatric Neurology Society Belgian Study Group of Multiple Sclerosis Belgian Stroke Council Belgian Headache Society Belgian Study Group of Neuropathology
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