反应实时监测工具，开发 "步行式自动反应剖析 "系统

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

The Journal of Organic Chemistry Pub Date : 2024-11-22 DOI:10.1021/acs.joc.4c02027

Muhammad Alimuddin, Louise Bernier, John F. Braganza, Michael R. Collins, Martha Ornelas, Paul F. Richardson, Neal Sach, Deszra Shariff, Wei Wang, Alex Yanovsky

{"title":"反应实时监测工具，开发 \"步行式自动反应剖析 \"系统","authors":"Muhammad Alimuddin, Louise Bernier, John F. Braganza, Michael R. Collins, Martha Ornelas, Paul F. Richardson, Neal Sach, Deszra Shariff, Wei Wang, Alex Yanovsky","doi":"10.1021/acs.joc.4c02027","DOIUrl":null,"url":null,"abstract":"Optimization of chemical reactions requires a thorough analysis of reaction products and intermediates over a given time course. Chemical reactions are often analyzed by liquid chromatography-mass spectrometry (LC-MS), but generating LC-MS samples and data analysis is time-consuming and produces a significant amount of waste. We sought to remove the sample preparation and data analysis steps by implementing an iChemExplorer/Agilent LC-MS instrument as our reactor and analysis tool, coupled with an automated report generator of reaction progress over time. Herein, we show that our easy-to-use walk-up automated reaction profiling (WARP) system can sample chemical reactions multiple times to produce a data-rich report of reaction progress over time.","PeriodicalId":57,"journal":{"name":"The Journal of Organic Chemistry","volume":"19 1","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Tool for Reaction Monitoring in Real Time, the Development of a “Walk-Up Automated Reaction Profiling” System\",\"authors\":\"Muhammad Alimuddin, Louise Bernier, John F. Braganza, Michael R. Collins, Martha Ornelas, Paul F. Richardson, Neal Sach, Deszra Shariff, Wei Wang, Alex Yanovsky\",\"doi\":\"10.1021/acs.joc.4c02027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Optimization of chemical reactions requires a thorough analysis of reaction products and intermediates over a given time course. Chemical reactions are often analyzed by liquid chromatography-mass spectrometry (LC-MS), but generating LC-MS samples and data analysis is time-consuming and produces a significant amount of waste. We sought to remove the sample preparation and data analysis steps by implementing an iChemExplorer/Agilent LC-MS instrument as our reactor and analysis tool, coupled with an automated report generator of reaction progress over time. Herein, we show that our easy-to-use walk-up automated reaction profiling (WARP) system can sample chemical reactions multiple times to produce a data-rich report of reaction progress over time.\",\"PeriodicalId\":57,\"journal\":{\"name\":\"The Journal of Organic Chemistry\",\"volume\":\"19 1\",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Organic Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.joc.4c02027\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Organic Chemistry","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1021/acs.joc.4c02027","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

要优化化学反应，就必须对给定时间过程中的反应产物和中间产物进行全面分析。化学反应通常采用液相色谱-质谱法（LC-MS）进行分析，但生成 LC-MS 样品和进行数据分析非常耗时，而且会产生大量废物。我们试图通过使用 iChemExplorer/Agilent LC-MS 仪器作为反应器和分析工具，并结合随时间推移的反应进展自动报告生成器，来消除样品制备和数据分析步骤。在此，我们展示了我们易于使用的步进式自动反应剖析（WARP）系统，该系统可以对化学反应进行多次采样，从而生成数据丰富的反应进展报告。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A Tool for Reaction Monitoring in Real Time, the Development of a “Walk-Up Automated Reaction Profiling” System

查看原文本刊更多论文

A Tool for Reaction Monitoring in Real Time, the Development of a “Walk-Up Automated Reaction Profiling” System

Optimization of chemical reactions requires a thorough analysis of reaction products and intermediates over a given time course. Chemical reactions are often analyzed by liquid chromatography-mass spectrometry (LC-MS), but generating LC-MS samples and data analysis is time-consuming and produces a significant amount of waste. We sought to remove the sample preparation and data analysis steps by implementing an iChemExplorer/Agilent LC-MS instrument as our reactor and analysis tool, coupled with an automated report generator of reaction progress over time. Herein, we show that our easy-to-use walk-up automated reaction profiling (WARP) system can sample chemical reactions multiple times to produce a data-rich report of reaction progress over time.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.