{"title":"不同步的丰度波动可驱动巨大的基因型频率波动","authors":"Joao A. Ascensao, Kristen Lok, Oskar Hallatschek","doi":"10.1038/s41559-024-02578-3","DOIUrl":null,"url":null,"abstract":"<p>Large stochastic population abundance fluctuations are ubiquitous across the tree of life, impacting the predictability and outcomes of population dynamics. It is generally thought that abundance fluctuations with a Taylor’s law exponent of two do not strongly impact evolution. However, we argue that such abundance fluctuations can lead to substantial genotype frequency fluctuations if different genotypes in a population experience these fluctuations asynchronously. By serially diluting mixtures of two closely related <i>Escherichia coli</i> strains, we show that such asynchrony can occur, leading to giant frequency fluctuations that far exceed expectations from genetic drift. We develop an effective model explaining that the abundance fluctuations arise from correlated offspring numbers between individuals, and the large frequency fluctuations result from (even slight) decoupling in offspring number correlations between genotypes. The model quantitatively predicts the observed abundance and frequency fluctuation scaling. Initially close trajectories diverge exponentially, suggesting that chaotic dynamics may underpin the excess frequency fluctuations. Our findings suggest that decoupling noise is also present in mixed-genotype <i>Saccharomyces cerevisiae</i> populations. Theoretical analyses demonstrate that decoupling noise can strongly influence evolutionary outcomes, in a manner distinct from genetic drift. Given the generic nature of these frequency fluctuations, we expect them to be widespread across biological populations.</p>","PeriodicalId":18835,"journal":{"name":"Nature ecology & evolution","volume":"115 1","pages":""},"PeriodicalIF":13.9000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Asynchronous abundance fluctuations can drive giant genotype frequency fluctuations\",\"authors\":\"Joao A. Ascensao, Kristen Lok, Oskar Hallatschek\",\"doi\":\"10.1038/s41559-024-02578-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Large stochastic population abundance fluctuations are ubiquitous across the tree of life, impacting the predictability and outcomes of population dynamics. It is generally thought that abundance fluctuations with a Taylor’s law exponent of two do not strongly impact evolution. However, we argue that such abundance fluctuations can lead to substantial genotype frequency fluctuations if different genotypes in a population experience these fluctuations asynchronously. By serially diluting mixtures of two closely related <i>Escherichia coli</i> strains, we show that such asynchrony can occur, leading to giant frequency fluctuations that far exceed expectations from genetic drift. We develop an effective model explaining that the abundance fluctuations arise from correlated offspring numbers between individuals, and the large frequency fluctuations result from (even slight) decoupling in offspring number correlations between genotypes. The model quantitatively predicts the observed abundance and frequency fluctuation scaling. Initially close trajectories diverge exponentially, suggesting that chaotic dynamics may underpin the excess frequency fluctuations. Our findings suggest that decoupling noise is also present in mixed-genotype <i>Saccharomyces cerevisiae</i> populations. Theoretical analyses demonstrate that decoupling noise can strongly influence evolutionary outcomes, in a manner distinct from genetic drift. Given the generic nature of these frequency fluctuations, we expect them to be widespread across biological populations.</p>\",\"PeriodicalId\":18835,\"journal\":{\"name\":\"Nature ecology & evolution\",\"volume\":\"115 1\",\"pages\":\"\"},\"PeriodicalIF\":13.9000,\"publicationDate\":\"2024-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature ecology & evolution\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1038/s41559-024-02578-3\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature ecology & evolution","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41559-024-02578-3","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ECOLOGY","Score":null,"Total":0}
Asynchronous abundance fluctuations can drive giant genotype frequency fluctuations
Large stochastic population abundance fluctuations are ubiquitous across the tree of life, impacting the predictability and outcomes of population dynamics. It is generally thought that abundance fluctuations with a Taylor’s law exponent of two do not strongly impact evolution. However, we argue that such abundance fluctuations can lead to substantial genotype frequency fluctuations if different genotypes in a population experience these fluctuations asynchronously. By serially diluting mixtures of two closely related Escherichia coli strains, we show that such asynchrony can occur, leading to giant frequency fluctuations that far exceed expectations from genetic drift. We develop an effective model explaining that the abundance fluctuations arise from correlated offspring numbers between individuals, and the large frequency fluctuations result from (even slight) decoupling in offspring number correlations between genotypes. The model quantitatively predicts the observed abundance and frequency fluctuation scaling. Initially close trajectories diverge exponentially, suggesting that chaotic dynamics may underpin the excess frequency fluctuations. Our findings suggest that decoupling noise is also present in mixed-genotype Saccharomyces cerevisiae populations. Theoretical analyses demonstrate that decoupling noise can strongly influence evolutionary outcomes, in a manner distinct from genetic drift. Given the generic nature of these frequency fluctuations, we expect them to be widespread across biological populations.
Nature ecology & evolutionAgricultural and Biological Sciences-Ecology, Evolution, Behavior and Systematics
CiteScore
22.20
自引率
2.40%
发文量
282
期刊介绍:
Nature Ecology & Evolution is interested in the full spectrum of ecological and evolutionary biology, encompassing approaches at the molecular, organismal, population, community and ecosystem levels, as well as relevant parts of the social sciences. Nature Ecology & Evolution provides a place where all researchers and policymakers interested in all aspects of life's diversity can come together to learn about the most accomplished and significant advances in the field and to discuss topical issues. An online-only monthly journal, our broad scope ensures that the research published reaches the widest possible audience of scientists.