对 SV2A 的结构洞察以及拉西坦类抗惊厥药的作用机制

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-11-22 DOI:10.1038/s41594-024-01430-3

Mazdak M. Bradberry, Edwin R. Chapman

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引用次数: 0

摘要

左乙拉西坦等乙酰胆碱类抗惊厥药被广泛用于治疗和预防癫痫发作。尽管已在临床上使用了几十年，但其作用机制仍不清楚。现在，两项研究揭示了与抗惊厥药物复合的拉西坦结合蛋白 SV2A 的结构，为了解它们的作用机制和神经传递的生理学提供了线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Structural insights into SV2A and the mechanism of racetam anticonvulsants

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Structural insights into SV2A and the mechanism of racetam anticonvulsants

Racetam anticonvulsants, such as levetiracetam, are widely prescribed to treat and prevent seizures. Despite decades of clinical use, their mechanism of action remains unclear. Two studies now reveal the structure of the racetam-binding protein SV2A in complex with anticonvulsant drugs, providing insights into their mechanism of action and the physiology of neurotransmission.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.