PIBD简化分类标准的验证:单中心回顾性研究

IF 1 4区 医学 Q3 PEDIATRICS
Yoshikazu Miura, Shin-Ichiro Hagiwara, Keinosuke Hizuka, Ryutaro Saura, Ayaha Hata, Takatoshi Maeyama, Yuri Etani
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引用次数: 0

摘要

背景:小儿炎症性肠病(PIBD)亚型是根据小儿炎症性肠病分类标准进行分类的,该标准包括 23 个项目。这些标准后来简化为 19 个诊断项目。炎症性肠病(IBD)分为溃疡性结肠炎(UC)、非典型 UC、未分类 IBD(IBD-U)、克罗恩病(CD)或孤立性结肠 CD。本研究的目的是在亚洲人群中验证简化的 PIBD 分类标准,并评估 IBD-U 的特征:方法:对2007年至2022年间确诊为PIBD的患者进行回顾性研究。从病历中收集了有关PIBD表型、诊断年龄、内镜和病理检查结果以及生物制剂和/或类固醇使用情况的数据。将医生指定的诊断与基于简化的 PIBD 类标准的诊断进行了比较。此外,还评估了IBD-U患者与使用简化PIBD-classes标准分类的其他IBD患者临床特征的差异:结果:共纳入86名患者,其中54人(63%)患有UC,21人(24%)患有CD,11人(13%)患有IBD-U。根据简化的 PIBD 分类标准,48 例(56%)患者被诊断为 UC,3 例(3%)患者被诊断为非典型 UC,22 例(26%)患者被诊断为 CD,1 例(1%)患者被诊断为孤立性结肠 CD,12 例(14%)患者被诊断为 IBD-U。根据简化的 PIBD 分类标准,有 10 例患者的诊断发生了变化。IBD亚型之间的诊断年龄、类固醇和生物制剂使用率没有明显差异:结论:在几乎所有病例中,基于简化 PIBD 分类标准的诊断与医生指定的诊断相吻合。这项研究表明,简化的PIBD分类标准有助于减少多中心和国际PIBD研究中的诊断变异性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Validation of the simplified PIBD-classes criteria: A single-center retrospective study.

Background: Pediatric inflammatory bowel disease (PIBD) subtypes are classified according to the PIBD-classes criteria, comprising 23 items. These criteria were later simplified to 19 diagnostic items. Inflammatory bowel diseases (IBDs) are classified as ulcerative colitis (UC), atypical UC, IBD-unclassified (IBD-U), Crohn's disease (CD), or isolated colonic CD. This study aimed to validate the simplified PIBD-classes criteria in an Asian population and evaluate IBD-U characteristics.

Methods: Patients diagnosed with PIBD between 2007 and 2022 were retrospectively enrolled. Data regarding PIBD phenotypes, age at diagnosis, endoscopic and pathological findings, and biologics and/or steroid use were collected from medical records. Physician-assigned diagnoses were compared with simplified PIBD-classes criteria-based diagnoses. Differences in the clinical features of patients with IBD-U and other IBDs classified using the simplified PIBD-class criteria were also evaluated.

Results: Eighty-six patients were included, of whom 54 (63%) had UC, 21 (24%) had CD, and 11 (13%) had IBD-U. Using the simplified PIBD-classes criteria, 48 (56%) patients were diagnosed with UC, 3 (3%) with atypical UC, 22 (26%) with CD, 1 (1%) with isolated colonic CD, and 12 (14%) with IBD-U. The diagnoses were changed in 10 cases based on the simplified PIBD-classes criteria. There were no significant differences in age at diagnosis or rates of steroid and biologic use between IBD subtypes.

Conclusions: Simplified PIBD-classes criteria-based diagnoses matched physician-assigned diagnoses in almost all cases. This study suggests that the simplified PIBD-classes criteria are useful at reducing diagnostic variability in multicenter and international PIBD studies.

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来源期刊
Pediatrics International
Pediatrics International 医学-小儿科
CiteScore
2.00
自引率
7.10%
发文量
519
审稿时长
12 months
期刊介绍: Publishing articles of scientific excellence in pediatrics and child health delivery, Pediatrics International aims to encourage those involved in the research, practice and delivery of child health to share their experiences, ideas and achievements. Formerly Acta Paediatrica Japonica, the change in name in 1999 to Pediatrics International, reflects the Journal''s international status both in readership and contributions (approximately 45% of articles published are from non-Japanese authors). The Editors continue their strong commitment to the sharing of scientific information for the benefit of children everywhere. Pediatrics International opens the door to all authors throughout the world. Manuscripts are judged by two experts solely upon the basis of their contribution of original data, original ideas and their presentation.
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