埃塞俄比亚丙型肝炎血清流行率:基于 2016 年埃塞俄比亚人口与健康调查的首次全国性研究。

IF 2.5 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Getahun Molla Kassa, Atsbeha Gebreegziabxier Weldemariam, Saro Abdella Abrahim, Clare E French, Dawit Wolday, Emebet Dagne, Andargachew Mulu, Aynishet Adane, Sarah K Inglis, Andrew Radley, Geremew Tasew, Peter Vickerman, Elias Ali Yesuf, Ora Paltiel, Mesay Hailu, Wondwossen Amogne, John F Dillon, Matthew Hickman, Aaron G Lim, Josephine G Walker
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引用次数: 0

摘要

丙型肝炎病毒(HCV)被认为是埃塞俄比亚的一个公共卫生问题,系统综述证据表明其血清流行率为 1%-3%。我们旨在估算埃塞俄比亚整体和各地区的丙型肝炎病毒血清流行率。我们利用 2016 年埃塞俄比亚人口与健康调查(EDHS-2016)估算了 HCV 血清流行率。EDHS-2016 是一项采用两阶段整群抽样方法进行的全国性家庭调查。我们使用 HCV 酶联免疫法检测了参与调查的成年女性(15-49 岁)和男性(15-59 岁)的全部 26753 份样本。我们根据《人口健康调查统计指南》进行了描述性分析。我们采用样本加权法得出了具有代表性的估计值。在接受检测的总人数中,一半以上(54.40%)为 15-29 岁,51.59% 为女性。整体 HCV 血清流行率为 0.18%(95% 置信区间:0.10-0.32)。阿法尔(0.92%)和南方各族人民地区(0.43%)、艾滋病毒感染者(0.62%)、最贫困人口(0.35%)、一生中有多个性伴侣者(0.31%)和丧偶/离婚者(0.30%)的血清阳性率较高。在按性别和居住地进行的分层分析中,我们发现非基督徒和非穆斯林男性(1.98%)和农村人口(1.00%)、男性 PLWH(1.67%)、农村 PLWH(1.45%)、丧偶/离异男性(0.97%)以及阿法尔地区所有群体中的血清流行率较高:男性(1.30%)、女性(0.61%)、城市(1.07%)和农村(0.86%)。埃塞俄比亚普通人群的丙型肝炎病毒血清阳性率远低于之前的估计值。普通人群筛查不太可能具有成本效益,因此需要针对感染 HCV 风险较高的人群开展筛查计划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seroprevalence of Hepatitis C in Ethiopia: First National Study Based on the 2016 Ethiopian Demographic and Health Survey.

Hepatitis C virus (HCV) is hypothesised to be a public health problem in Ethiopia, and systematic review evidence suggested 1%-3% seroprevalence. We aimed to estimate the seroprevalence of HCV overall and across regions of Ethiopia. We estimated HCV seroprevalence using the 2016 Ethiopian Demographic and Health Survey (EDHS-2016). EDHS-2016 is a nationwide household survey conducted using two-stage cluster sampling methods. We tested all 26,753 samples from participating adult women (15-49 years) and men (15-59 years) using HCV Enzyme Immunoassay. Descriptive analyses were performed based on the Guide to Demographic Health Survey statistics. We applied sample weighting to derive representative estimates. Of the total tested, more than half (54.40%) were aged 15-29 years and 51.59% were women. Overall HCV seroprevalence was 0.18% (95% Confidence Interval: 0.10-0.32). Higher seroprevalences were found in Afar (0.92%) and South Nations Nationality Peoples Region (0.43%); people living with HIV (PLWH) (0.62%); the poorest wealth index (0.35%); people having multiple lifetime sexual partners (0.31%); and widowed/divorced individuals (0.30%). In stratified analyses by sex and residency, we found higher seroprevalences in non-Christian and non-Muslim males (1.98%) and rural population (1.00%), male PLWH (1.67%), rural PLWH (1.45%), widowed/divorced males (0.97%), and in all groups from the Afar region: males (1.30%), females (0.61%), urban (1.07%), and rural (0.86%). HCV seroprevalence among the general population in Ethiopia is much lower than from previous estimates. General population screening is unlikely to be cost-effective, and so screening programs targeted to people at greater risk of HCV will be required.

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来源期刊
Journal of Viral Hepatitis
Journal of Viral Hepatitis 医学-病毒学
CiteScore
6.00
自引率
8.00%
发文量
138
审稿时长
1.5 months
期刊介绍: The Journal of Viral Hepatitis publishes reviews, original work (full papers) and short, rapid communications in the area of viral hepatitis. It solicits these articles from epidemiologists, clinicians, pathologists, virologists and specialists in transfusion medicine working in the field, thereby bringing together in a single journal the important issues in this expanding speciality. The Journal of Viral Hepatitis is a monthly journal, publishing reviews, original work (full papers) and short rapid communications in the area of viral hepatitis. It brings together in a single journal important issues in this rapidly expanding speciality including articles from: virologists; epidemiologists; clinicians; pathologists; specialists in transfusion medicine.
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