妊娠期 COVID-19 的发生时间和严重程度会影响围产期和新生儿预后吗？

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2024-11-21 DOI:10.1038/s41372-024-02179-9

Júlia Candel-Pau, Daniel Suqué-Tusell, Sílvia Maya-Enero, Carlos Ramon-Iglesias, Beatriz Valle-Del-Barrio, Maria Ángeles López-Vílchez

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引用次数: 0

摘要

研究目的研究设计：前瞻性队列研究。2020 年至 2022 年期间在巴塞罗那德尔马医院（Hospital del Mar）出生的新生儿根据其母亲孕期的 COVID-19 状态分为两个队列。根据母亲感染的时间和严重程度，比较 COVID-19 和对照组的产前和产后变量：结果：我们纳入了 2701 名新生儿，观察到 COVID-19 组群中呼吸窘迫（5.7% vs 3.3%，p = 0.044）和病理性黄疸（7.7% vs 4.1%，p = 0.007）的发生率较高，但不同孕期的发生率并无差异。在其他围产期结果方面，我们没有发现有统计学意义的差异。逻辑回归分析表明，母亲 COVID-19 并非早产的风险因素（OR:1.23;CI:0.75-2.03; p = 0.407）：结论：在我院，妊娠期感染COVID-19的母亲所生婴儿的呼吸窘迫和病理性黄疸发生率较高，但早产或其他疾病的发生率并未增加。

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Do timing and severity of gestational COVID-19 impact perinatal and neonatal outcomes?

Objective: To examine the relationship between gestational COVID-19 and perinatal-neonatal outcomes.

Study design: Prospective cohort study. Neonates born at Hospital del Mar (Barcelona) between 2020 and 2022 were classified into two cohorts according to their mother's COVID-19 status during pregnancy. Prenatal and postnatal variables were compared between the COVID-19 and the control cohort, and depending on timing and severity of maternal infection.

Results: We included 2701 neonates and observed higher rates of respiratory distress (5.7% vs 3.3%, p = 0.044) and pathological jaundice (7.7% vs 4.1%, p = 0.007) in the COVID-19 cohort, without differences between trimesters. We did not find statistically significant differences in other perinatal outcomes. The logistic regression analyses showed that maternal COVID-19 was not a risk factor for prematurity (OR:1.23;CI:0.75-2.03; p = 0.407).

Conclusions: Infants born to mothers with COVID-19 during pregnancy in our hospital showed higher rates of respiratory distress and pathological jaundice, without increased rates of prematurity or other morbidities.

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.