Talarindigotin A：一种细胞毒性靛红衍生物，来自红树林内生真菌 Talaromyces amestolkiae SCNU-F0041。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-11-20 DOI:10.1080/10286020.2024.2428228

Jia-Lin Li, Ling-Ling Liu, Zi-Rong Lin, Hai-Qi Zeng, Zhe Zhou, Yu-Hua Long

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引用次数: 0

摘要

研究人员从红树林内生真菌 Talaromyces amestolkiae SCNU-F0041 中分离出一种新的吲哚生物碱，命名为 Talarindigotin A（1），以及类似物 5H，6H-quinindolin-11-one（2）。根据 NMR、HRMS 和单晶 X 射线衍射分析确定了它们的结构。在细胞毒性生物测定中，化合物 1 对 HepG2、Hela、HCT116 和 Huh7 人类癌细胞株具有很强的细胞毒性，其 IC50 值介于 2.08 至 4.58 μM 之间。

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Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041.

A new indigotin alkaloid, named talarindigotin A (1), along with the analogue 5H, 6H-quinindolin-11-one (2) were isolated from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound 1 showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC₅₀ values ranging from 2.08 to 4.58 μM.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.