哈萨克斯坦北部和南部地区阿尔茨海默病患者的载脂蛋白 E 基因多态性与临床、生化和社会人口学特征。

IF 3.6 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Gulnaz Zholdasbekova, Aiym Kaiyrlykyzy, Aliya Kassenova, Dinara Alzhanova, Dmitry Klyuev, Sholpan Askarova
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引用次数: 0

摘要

背景:阿尔茨海默病(AD)是导致老年人痴呆症的最常见原因,也是现代医疗保健领域的重要社会问题之一。由于阿兹海默病被认为是一种多因素疾病,因此人们一直在重新评估特定风险因素在不同种族人群中的重要性:研究组包括 181 名注意力缺失症患者,对照组包括 244 名健康老人,其性别和年龄与痴呆症组相当。我们的研究比较了哈萨克斯坦北部(阿斯塔纳市)和南部(阿拉木图市)地区被诊断为AD患者的临床数据、血液生化指标、各种社会人口特征和载脂蛋白E基因多态性:在我们的队列中,与痴呆相关的重要变量包括吸烟、临床上明显的抑郁、血脂异常、糖代谢受损、胰岛素抵抗和肝功能异常。值得注意的是,AD 患者的高密度脂蛋白水平较高,谷丙转氨酶水平较低,总胆红素和谷草转氨酶/谷丙转氨酶比率较高。载脂蛋白E ɛ4基因型是众所周知的注意力缺失症风险因素,在北部注意力缺失症组中更为普遍。此外,阿斯塔纳市的参与者中风发病率较高,这可能与低密度脂蛋白水平升高有关,而阿拉木图市的居民临床严重抑郁症发病率较高:讨论:这些发现强调了在注意力缺失症研究中考虑生物地理和环境因素的重要性。讨论:这些发现强调了在注意力缺失症研究中考虑生物地理和环境因素的重要性,研究结果可能有助于进一步研究和开发个性化方法,以管理和治疗不同地理区域的注意力缺失症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

ApoE Gene Polymorphism and Clinical, Biochemical, and Sociodemographic Characteristics of Alzheimer's Disease Patients From Northern and Southern Regions of Kazakhstan

ApoE Gene Polymorphism and Clinical, Biochemical, and Sociodemographic Characteristics of Alzheimer's Disease Patients From Northern and Southern Regions of Kazakhstan

Background

Alzheimer's disease (AD) is the most frequent cause of dementia in seniors and is also one of the critical social issues of modern healthcare. Since AD is considered a multifactorial disease, the significance of particular risk factors in different ethnic populations is constantly reevaluated.

Method

The study group consisted of 181 patients with AD, and the control group included 244 healthy seniors comparable in sex and age to the dementia group. Our study compared clinical data, blood biochemical parameters, various sociodemographic characteristics, and ApoE gene polymorphism in patients diagnosed with AD from Kazakhstan's north (Astana city) and south (Almaty city) regions.

Results

In our cohort, significant dementia-associated variables included smoking, clinically significant depression, dyslipidemia, impaired glucose metabolism, insulin resistance, and liver dysfunction. Notably, AD patients had higher HDL levels, lower ALT levels, and higher total bilirubin and AST/ALT ratios. The ApoE ɛ4 genotype, a well-known AD risk factor, was more prevalent in the northern AD group. Additionally, participants from Astana city had a higher incidence of strokes, potentially linked to elevated LDL levels, while Almaty city residents exhibited a higher prevalence of clinically severe depression.

Discussion

These findings underscore the importance of considering bio-geographic and environmental factors in AD research. The study's outcomes may aid in further research and the development of personalized approaches for managing and treating AD in distinct geographical regions.

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来源期刊
CiteScore
6.10
自引率
2.50%
发文量
168
审稿时长
4-8 weeks
期刊介绍: The rapidly increasing world population of aged people has led to a growing need to focus attention on the problems of mental disorder in late life. The aim of the Journal is to communicate the results of original research in the causes, treatment and care of all forms of mental disorder which affect the elderly. The Journal is of interest to psychiatrists, psychologists, social scientists, nurses and others engaged in therapeutic professions, together with general neurobiological researchers. The Journal provides an international perspective on the important issue of geriatric psychiatry, and contributions are published from countries throughout the world. Topics covered include epidemiology of mental disorders in old age, clinical aetiological research, post-mortem pathological and neurochemical studies, treatment trials and evaluation of geriatric psychiatry services.
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