中性粒细胞淋巴细胞比值可预测前循环卒中患者的早期神经功能衰退

IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of General Medicine Pub Date : 2024-11-16 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S472316
Lingling Zhao, Shuyu Zhou, Qiliang Dai, Junrong Li
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引用次数: 0

摘要

背景:急性缺血性卒中的早期神经功能恶化(END)可导致临床预后显著恶化。中性粒细胞淋巴细胞比值(NLR)与卒中严重程度有关,可能是急性缺血性卒中短期死亡率的预测因子。本研究探讨了前循环卒中患者 NLR 与END 之间的关系:方法:对症状出现后 24 小时内入院的首次急性缺血性卒中患者进行分析。根据入院后 24 小时内获得的实验室参数计算 NLR。记录入院后 72 小时内的END发生率。多变量逻辑回归用于研究 NLR 和 END 之间的关系:我们纳入了 228 名症状出现后 24 小时内的连续患者进行最终分析。共有 64 人(28.1%)在入院后 72 小时内出现了END。END患者入院时NLR较高(中位数NLR为3.8 vs 2.4; p2.65 (OR, 4.019; 95% CI, 1.937-8.337; p2.65),住院时间较长(中位数住院时间为12 vs 4; p结论:本研究发现,NLR 是前循环卒中患者END 的独立预测因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neutrophil Lymphocyte Ratio Predicts Early Neurological Deterioration in Patients with Anterior Circulation Stroke.

Background: Early neurologic deterioration (END) in acute ischemic stroke could result in significant worsening of clinical prognosis. Neutrophil lymphocyte ratio (NLR) is related to stroke severity and might be a predictor of short-term mortality in acute ischemic stroke. This study investigated the relationship between NLR and END in anterior circulation stroke patients.

Methods: Consecutive patients with first-ever acute ischemic stroke admitted to hospital within 24-hour of symptom onset were analyzed. NLR was calculated according to the Laboratory parameters obtained during the first 24 hours after admission. The rate of the END was recorded during the first 72-hours of admission. Multivariate logistic regression was applied to investigate the relationship between NLR and END.

Results: We included 228 consecutive patients within 24-hours of symptom onset for the final analysis. In total, 64 (28.1%) experienced END during the first 72 hours after admission. Patients with END were more likely to have higher NLR (median NLR 3.8 vs 2.4; p<0.001) compared with those without END. Multivariate logistic regression revealed that NLR>2.65 (OR, 4.019; 95% CI, 1.937-8.337; p<0.001) was an independent predictor of END. Also, patients in high NLR subgroup (NLR>2.65) at admission were more likely to have prolonged length of stays (median length of stays 12 vs 4; p<0.001).

Conclusion: This study found NLR was an independent predictor of END in patients with anterior circulation stroke.

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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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