Jia-Nan Sun, Yu Li, Meng Luan, Lang Wu, Fang-Hua Liu, Yi-Zi Li, He-Li Xu, Yi-Fan Wei, Qian Xiao, Xiao-Ying Li, Jin Xu, Ke-Xin Liu, Dong-Hui Huang, Qi-Jun Wu, Ting-Ting Gong
{"title":"多酚摄入前后与卵巢癌生存率:一项前瞻性队列研究的证据。","authors":"Jia-Nan Sun, Yu Li, Meng Luan, Lang Wu, Fang-Hua Liu, Yi-Zi Li, He-Li Xu, Yi-Fan Wei, Qian Xiao, Xiao-Ying Li, Jin Xu, Ke-Xin Liu, Dong-Hui Huang, Qi-Jun Wu, Ting-Ting Gong","doi":"10.1007/s00394-024-03516-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Although (poly)phenols have shown potential in anti-cancer activities, their impact on improving ovarian cancer (OC) survival remains unknown. Therefore, we aim to first investigate the association between dietary polyphenol intake and OC survival, providing valuable insights into potential interventions.</p><p><strong>Methods: </strong>The prospective cohort recruited 560 patients with OC to assess the associations of polyphenol intake, not only pre- and post-diagnosis but also the change from pre- to post-diagnosis with OC survival. Dietary intakes of total (poly)phenols and their five classes (flavonoids, phenolic acids, lignans, stilbenes, and other polyphenols) were assessed using a validated 111-item food frequency questionnaire. Overall survival (OS) was tracked through active follow-up and medical records until February 16th, 2023. Cox proportional hazard regression models were applied to calculate the hazard ratios (HR) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>During a median follow-up of 44.4 months, 211 all-cause deaths were identified. We observed significant associations between higher polyphenol intake with lower risk of mortality among patients with OC ((HR <sub>T3 vs. T1</sub> = 0.55, 95%CI = 0.35-0.87 for pre-diagnosis; and HR <sub>T3 vs. T1</sub> = 0.59, 95%CI = 0.39-0.90 for post-diagnosis). Consistently, an evident linear trend was observed for polyphenol and flavonoid intake with OC survival. Of note, compared to the stable group (change within 10%), the decreased intake (change of more than 10%) of total (poly)phenols and five polyphenol classes was significantly associated with worse OS.</p><p><strong>Conclusion: </strong>Dietary (poly)phenols, as well as its five classes, have an inverse association with OC survival.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"14"},"PeriodicalIF":4.1000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pre- and post-polyphenol intake and ovarian cancer survival: evidence from a prospective cohort study.\",\"authors\":\"Jia-Nan Sun, Yu Li, Meng Luan, Lang Wu, Fang-Hua Liu, Yi-Zi Li, He-Li Xu, Yi-Fan Wei, Qian Xiao, Xiao-Ying Li, Jin Xu, Ke-Xin Liu, Dong-Hui Huang, Qi-Jun Wu, Ting-Ting Gong\",\"doi\":\"10.1007/s00394-024-03516-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Although (poly)phenols have shown potential in anti-cancer activities, their impact on improving ovarian cancer (OC) survival remains unknown. Therefore, we aim to first investigate the association between dietary polyphenol intake and OC survival, providing valuable insights into potential interventions.</p><p><strong>Methods: </strong>The prospective cohort recruited 560 patients with OC to assess the associations of polyphenol intake, not only pre- and post-diagnosis but also the change from pre- to post-diagnosis with OC survival. Dietary intakes of total (poly)phenols and their five classes (flavonoids, phenolic acids, lignans, stilbenes, and other polyphenols) were assessed using a validated 111-item food frequency questionnaire. Overall survival (OS) was tracked through active follow-up and medical records until February 16th, 2023. Cox proportional hazard regression models were applied to calculate the hazard ratios (HR) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>During a median follow-up of 44.4 months, 211 all-cause deaths were identified. We observed significant associations between higher polyphenol intake with lower risk of mortality among patients with OC ((HR <sub>T3 vs. T1</sub> = 0.55, 95%CI = 0.35-0.87 for pre-diagnosis; and HR <sub>T3 vs. T1</sub> = 0.59, 95%CI = 0.39-0.90 for post-diagnosis). Consistently, an evident linear trend was observed for polyphenol and flavonoid intake with OC survival. Of note, compared to the stable group (change within 10%), the decreased intake (change of more than 10%) of total (poly)phenols and five polyphenol classes was significantly associated with worse OS.</p><p><strong>Conclusion: </strong>Dietary (poly)phenols, as well as its five classes, have an inverse association with OC survival.</p>\",\"PeriodicalId\":12030,\"journal\":{\"name\":\"European Journal of Nutrition\",\"volume\":\"64 1\",\"pages\":\"14\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-11-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00394-024-03516-6\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00394-024-03516-6","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
摘要
目的:虽然(多)酚具有潜在的抗癌活性,但它们对改善卵巢癌(OC)生存率的影响仍然未知。因此,我们旨在首先研究膳食多酚摄入量与卵巢癌患者生存率之间的关系,为潜在的干预措施提供有价值的见解:前瞻性队列招募了560名OC患者,评估多酚摄入量与OC存活率的关系,不仅包括诊断前和诊断后的多酚摄入量,还包括从诊断前到诊断后的多酚摄入量变化。该研究采用经过验证的111项食物频率问卷,评估了膳食中总(多)酚及其五类多酚(类黄酮、酚酸、木脂素、二苯乙烯类和其他多酚)的摄入量。通过积极的随访和医疗记录追踪总生存期(OS),直至 2023 年 2 月 16 日。采用考克斯比例危险回归模型计算危险比(HR)和95%置信区间(CI):结果:在44.4个月的中位随访期间,共发现211例全因死亡病例。我们发现,多酚摄入量越高,OC 患者的死亡风险越低(诊断前 HR T3 vs. T1 = 0.55,95%CI = 0.35-0.87;诊断后 HR T3 vs. T1 = 0.59,95%CI = 0.39-0.90)。同样,多酚和类黄酮摄入量与 OC 存活率呈明显的线性趋势。值得注意的是,与稳定组(变化在10%以内)相比,总(多)酚和五类多酚摄入量的减少(变化超过10%)与OS恶化显著相关:结论:膳食(多)酚及其五类多酚与卵巢癌患者的生存率呈负相关。
Pre- and post-polyphenol intake and ovarian cancer survival: evidence from a prospective cohort study.
Purpose: Although (poly)phenols have shown potential in anti-cancer activities, their impact on improving ovarian cancer (OC) survival remains unknown. Therefore, we aim to first investigate the association between dietary polyphenol intake and OC survival, providing valuable insights into potential interventions.
Methods: The prospective cohort recruited 560 patients with OC to assess the associations of polyphenol intake, not only pre- and post-diagnosis but also the change from pre- to post-diagnosis with OC survival. Dietary intakes of total (poly)phenols and their five classes (flavonoids, phenolic acids, lignans, stilbenes, and other polyphenols) were assessed using a validated 111-item food frequency questionnaire. Overall survival (OS) was tracked through active follow-up and medical records until February 16th, 2023. Cox proportional hazard regression models were applied to calculate the hazard ratios (HR) and 95% confidence intervals (CI).
Results: During a median follow-up of 44.4 months, 211 all-cause deaths were identified. We observed significant associations between higher polyphenol intake with lower risk of mortality among patients with OC ((HR T3 vs. T1 = 0.55, 95%CI = 0.35-0.87 for pre-diagnosis; and HR T3 vs. T1 = 0.59, 95%CI = 0.39-0.90 for post-diagnosis). Consistently, an evident linear trend was observed for polyphenol and flavonoid intake with OC survival. Of note, compared to the stable group (change within 10%), the decreased intake (change of more than 10%) of total (poly)phenols and five polyphenol classes was significantly associated with worse OS.
Conclusion: Dietary (poly)phenols, as well as its five classes, have an inverse association with OC survival.
期刊介绍:
The European Journal of Nutrition publishes original papers, reviews, and short communications in the nutritional sciences. The manuscripts submitted to the European Journal of Nutrition should have their major focus on the impact of nutrients and non-nutrients on
immunology and inflammation,
gene expression,
metabolism,
chronic diseases, or
carcinogenesis,
or a major focus on
epidemiology, including intervention studies with healthy subjects and with patients,
biofunctionality of food and food components, or
the impact of diet on the environment.