甲基化测序增强了对克隆造血动态的解读。

IF 21 1区医学 Q1 HEMATOLOGY

Blood Pub Date : 2024-11-20 DOI:10.1182/blood.2024026555

Alyssa C Parker, Joseph Van Amburg, J Brett Heimlich, Yash Pershad, Nicole Angelina Mickels, Taralynn Mack, Paul Brent Ferrell, Michael R Savona, Angela Jones, Alexander G Bick

引用次数: 0

摘要

我们开发了一种经济有效的 DNA 甲基化测序分析方法，以改善对克隆造血的监测。通过推断细胞类型比例，这种方法比仅根据变异等位基因比例来解读克隆轨迹更有说服力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics.

We have developed a cost-effective DNA methylation sequencing assay to improve monitoring of clonal hematopoiesis. By inferring cell-type proportions, this method enhances interpretation of clonal trajectories compared to interpretation based on variant allele fraction only.

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来源期刊

Blood 医学-血液学

CiteScore

23.60

自引率

3.90%

发文量

955

审稿时长

1 months

期刊介绍： Blood, the official journal of the American Society of Hematology, published online and in print, provides an international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology. Primary research articles will be published under the following scientific categories: Clinical Trials and Observations; Gene Therapy; Hematopoiesis and Stem Cells; Immunobiology and Immunotherapy scope; Myeloid Neoplasia; Lymphoid Neoplasia; Phagocytes, Granulocytes and Myelopoiesis; Platelets and Thrombopoiesis; Red Cells, Iron and Erythropoiesis; Thrombosis and Hemostasis; Transfusion Medicine; Transplantation; and Vascular Biology. Papers can be listed under more than one category as appropriate.