Association of magnesium intake with predicted atherosclerotic lesions and cardiovascular risk in young adults based on PDAY score: a cross-sectional study.

Background: Magnesium deficiency has been shown to accelerate atherosclerosis. We hypothesized that dietary magnesium intake at a young age is associated with future atherosclerotic lesions and cardiovascular risk in a large, nationally representative cohort of U.S. adults.

Methods: We included U.S. adults aged 20 to 34 years old from the National Health and Nutrition Examination Survey (NHANES) 2007 to 2018, a population-based cross-sectional study. Dietary magnesium intake was assessed using 24-hour diet recalls. Atherosclerotic lesions in the young adult population were predicted by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) score that was based on age, sex, smoking status, lipids, blood pressure, and obesity. Information on cardiovascular disease (CVD) risk factors including hypertension, non-HDL-C dyslipidemia, and diabetes was also collected. We used multivariable logistic analysis models to test the association between magnesium intake levels and the PDAY score and CVD risk factors, respectively, after adjusting for several potential confounding factors.

Results: 7,244 eligible participants were included in the analysis. The magnesium intake level was classified into three categories based on the tertile distribution in the population (i.e., ≤ 224, 225-340, and ≥ 341 mg/day). Compared with the lowest tertile, the multivariable-adjusted odds ratio (OR) and 95% confidence interval (95% CI) for the PDAY score were 0.83 (95% CI, 0.72 to 0.96) and 0.60 (95% CI, 0.49 to 0.74) in the second and the third tertiles of magnesium intake, respectively (P value for trend < 0.001), and there was a negative dose-response relationship (test for trend P value < 0.001). In addition, the highest dietary magnesium intake was significantly inverse associated with non-HDL-C dyslipidemia compared with the lowest magnesium intake (OR = 0.65; 95% CI, 0.46 to 0.91).

Conclusions: Dietary magnesium intake is inversely associated with the risk of future cardiovascular events assessed by the PDAY score and non-HDL-C dyslipidemia in young adulthood years.