大疱性类天疱疮中 JAK/STAT 信号的表达。

IF 2.2 4区医学 Q2 DERMATOLOGY

Australasian Journal of Dermatology Pub Date : 2024-11-21 DOI:10.1111/ajd.14389

Laxmi Iyengar, Patrick Hosking, Joel Dowsett, John Su

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引用次数: 0

摘要

在本研究中，我们分析了大疱性类天疱疮（BP）中 JAK/STAT 信号的表达特征。我们利用活检证实的大疱性类天疱疮患者的正常皮肤、病变和周围皮肤的冲孔活检标本，用市售的磷酸化 STAT 1、2、3、5A 和 6 抗体（Genesearch，美国）进行免疫过氧化物酶标记。定量分析显示，与正常皮肤相比，磷酸化 STAT 2、3、5A 和 6 在 BP 中过度表达。

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Expression of JAK/STAT signalling in bullous pemphigoid.

In the present study, we characterise the expression of JAK/STAT signalling in Bullous Pemphigoid (BP). Punch biopsy specimens of normal skin, lesional and perilesional skin of patients diagnosed with biopsy proven BP were utilised for immunoperoxidase labelling with commercially available antibodies for Phosphorylated STAT 1,2,3,5A and 6 (Genesearch, USA). Quantitative analysis demonstrated that in comparison to normal skin, phosphorylated STAT 2, 3, 5A and 6 were overexpressed in BP.

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来源期刊

Australasian Journal of Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

5.00%

发文量

186

审稿时长

6-12 weeks

期刊介绍： Australasian Journal of Dermatology is the official journal of the Australasian College of Dermatologists and the New Zealand Dermatological Society, publishing peer-reviewed, original research articles, reviews and case reports dealing with all aspects of clinical practice and research in dermatology. Clinical presentations, medical and physical therapies and investigations, including dermatopathology and mycology, are covered. Short articles may be published under the headings ‘Signs, Syndromes and Diagnoses’, ‘Dermatopathology Presentation’, ‘Vignettes in Contact Dermatology’, ‘Surgery Corner’ or ‘Letters to the Editor’.