感应亚铜离子的近红外荧光探针

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical Pub Date : 2024-11-20 DOI:10.1016/j.snb.2024.136982

Meirong Yi, Jintao Zhao, Ruipeng Shen, Tao Ma, Jingwen Tu, Xinming Li, Baoxin Zhang, Jianguo Fang

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引用次数: 0

摘要

铜的氧化还原特性以及 Cu(I) 和 Cu(II) 之间的相互转化对许多生理过程都至关重要。铜的缺乏或过量都可能导致疾病。在这项工作中，基于 Cu(I) 与硫醚四价配体支架之间的配位化学反应，报告了一种用于选择性识别 Cu(I) 的新型荧光探针（NS-5）。该探针具有多种有利特性，如近红外（NIR）发射（λem = 720 nm）、可在水介质中工作、荧光显著增强（13 倍）和线粒体定位。Cu(I) 在活细胞和小鼠体内的成功成像证明了该探针的实际应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A Near-infrared Fluorescent Probe for Sensing Cuprous ions

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A Near-infrared Fluorescent Probe for Sensing Cuprous ions

The redox character of copper with interconversion between Cu(I) and Cu(II) is essential for many physiological processes. Either deficiency or excess of copper may lead to disease conditions. In this work, a novel fluorescent probe (NS-5) for selective recognition of Cu(I) was reported based on the coordination chemistry between Cu(I) and the thioether tetradentate ligand scaffold. The probe features multiple favorable properties, such as near-infrared (NIR) emission (λ_em = 720 nm), working in aqueous media, significant fluorescence increase (>13-fold) and preferable mitochondrial localization. The successful imaging of Cu(I) in live cells and mouse demonstrates the practical applications of the probe.

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来源期刊

Sensors and Actuators B: Chemical 工程技术-电化学

CiteScore

14.60

自引率

11.90%

发文量

1776

审稿时长

3.2 months

期刊介绍： Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.