重装NAD黑客入侵细菌防御系统

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2024-11-21 DOI:10.1016/j.chembiol.2024.10.012

Arturo Carabias, Guillermo Montoya

引用次数: 0

摘要

烟酰胺腺嘌呤二核苷酸（NAD）是一种重要的代谢物，消耗它是细菌对抗噬菌体（噬菌体）的一种常见免疫策略。在最近一期的《自然》杂志上，Osterman 等人1 揭示了两种噬菌体编码的 NAD 恢复途径，展示了噬菌体对抗细菌免疫的创新策略，并为开发新型抗菌方法提供了启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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NAD reloaded: Hacking bacterial defenses

Nicotinamide adenine dinucleotide (NAD) is an essential metabolite, and its depletion serves as a common bacterial immune strategy against bacteriophages (phages). In a recent issue of Nature, Osterman et al.¹ reveal two phage-encoded NAD restoration pathways, showcasing the phages’ innovative counterstrategies against bacterial immunity and providing insights for developing novel antimicrobial approaches.

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.