Early wound healing in guided bone regeneration procedures using sodium hyaluronate and a pool of amino acids: a randomized clinical trial.

Background: Soft tissue healing is of paramount importance when guided bone regeneration techniques are used, as early exposure of the membrane could affect the results.

Methods: In this randomized clinical trial, enrolling 20 patients, a gel rich in hyaluronic acid and amino acids was used to promote wound healing after a ridge augmentation procedure. The Early Wound Healing Index - EHS was used to assess soft tissue healing by primary intention following surgery at 1, 3, 7 and 14 days.

Results: Results showed faster tissue healing when hyaluronic acid mixed with amino acids was used, and also a lower perception of pain by patients measured with a VAS scale.

Conclusions: These data suggest the creation of larger research studies that can support the use of biologics for early soft tissue healing.