大脑心理压力复原力的超微结构特征:小胶质细胞视角。

IF 4.5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Open Biology Pub Date : 2024-11-01 Epub Date: 2024-11-20 DOI:10.1098/rsob.240079
Fernando González Ibáñez, Jared VanderZwaag, Jessica Deslauriers, Marie-Ève Tremblay
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引用次数: 0

摘要

心理压力是导致重度抑郁症的主要风险因素。持续的压力会导致行为、大脑连接及其细胞和细胞器发生变化。对压力的复原力被理解为以积极的方式从压力中恢复的能力或抵抗心理压力负面影响的能力。小胶质细胞是大脑中的常驻免疫细胞,是已知的压力易感性的参与者,但人们对它们在压力恢复能力中的作用以及所涉及的细胞变化却知之甚少。超微结构分析一直是研究小胶质细胞及其在健康和疾病环境中的功能的有用工具。尽管使用电子显微镜的机会越来越多,但对电子显微图像的解读却仍然不那么容易。在这篇综述中,我们将首先介绍小胶质细胞以及心理压力易感性和恢复力的概念。随后,我们将介绍超微结构分析,特别是小胶质细胞的超微结构分析,以此作为研究心理压力复原力的基础机制的一种读出方法。最后,我们将介绍营养酮病作为一种治疗干预措施,在促进心理压力复原力以及改变小胶质细胞功能和超微结构方面的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ultrastructural features of psychological stress resilience in the brain: a microglial perspective.

Psychological stress is the major risk factor for major depressive disorder. Sustained stress causes changes in behaviour, brain connectivity and in its cells and organelles. Resilience to stress is understood as the ability to recover from stress in a positive way or the resistance to the negative effects of psychological stress. Microglia, the resident immune cells of the brain, are known players of stress susceptibility, but less is known about their role in stress resilience and the cellular changes involved. Ultrastructural analysis has been a useful tool in the study of microglia and their function across contexts of health and disease. Despite increased access to electron microscopy, the interpretation of electron micrographs remains much less accessible. In this review, we will first present microglia and the concepts of psychological stress susceptibility and resilience. Afterwards, we will describe ultrastructural analysis, notably of microglia, as a readout to study the mechanisms underlying psychological stress resilience. Lastly, we will cover nutritional ketosis as a therapeutic intervention that was shown to be effective in promoting psychological stress resilience as well as modifying microglial function and ultrastructure.

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来源期刊
Open Biology
Open Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
10.00
自引率
1.70%
发文量
136
审稿时长
6-12 weeks
期刊介绍: Open Biology is an online journal that welcomes original, high impact research in cell and developmental biology, molecular and structural biology, biochemistry, neuroscience, immunology, microbiology and genetics.
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