评估多波长微针贴片激光对过敏性鼻炎的治疗潜力：过敏性鼻炎小鼠模型的启示。

IF 2.2 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2024-11-19 DOI:10.1002/lsm.23862

Reiza Ventura, Jun-Sang Bae, Eun Hee Kim, A. Young Kim, Min Hyuck Oh, Ji Hye Kim, Shin Hyuk Yoo, Gwanghui Ryu, Ji-Hun Mo

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引用次数: 0

摘要

目的：目前还没有足够的证据来确定贴片激光治疗过敏性鼻炎的效果，而不是直接鼻腔内照射鼻粘膜。我们旨在评估多波长微针贴片激光在过敏性鼻炎（AR）小鼠模型中的效果及其内在机制：方法：将微针贴片激光器贴在小鼠鼻腔上方的皮肤上，向鼻粘膜发射光。在10天内，微针贴片激光器同时照射波长为670、780、850和910纳米的激光，每天照射10或20分钟。微针贴片激光治疗后，对多种过敏参数进行了评估：结果：微针贴片激光治疗减轻了过敏症状，抑制了 OVA 特异性 IgE 水平。结果：微针贴片激光治疗减轻了过敏症状，抑制了 OVA 特异性 IgE 水平，还明显减少了嗜酸性粒细胞浸润、鼻黏膜上皮厚度和 IL-4 细胞因子水平：结论：贴在皮肤上的微针贴片激光器发出的光可有效穿透鼻腔内的鼻粘膜，这表明它具有治疗小鼠过敏性鼻炎的潜力，并可推广到临床应用中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Evaluating the Therapeutic Potential of Microneedle Patch Laser With Multiple Wavelengths in Allergic Rhinitis: Insights From an Allergic Rhinitis Mouse Model

Objective

There is insufficient evidence to determine the effectiveness of treating allergic rhinitis with a patch laser affix to the skin as opposed to direct intranasal irradiation of the nasal mucosa. We aimed to evaluate the effect of the microneedle patch laser with multiple wavelengths in an allergic rhinitis (AR) mouse model and its underlying mechanism.

Methods

The microneedle patch laser was attached to the skin above the mouse's nasal cavity, transmitting light to the nasal mucosa. For 10 days, the microneedle patch laser administered simultaneous exposure to wavelengths of 670, 780, 850, and 910 nm at either 10 or 20 min each day. Multiple allergic parameters were evaluated following the microneedle patch laser treatment.

Results

Microneedle patch laser treatment decreased allergic symptoms and inhibited OVA-specific IgE levels. Additionally, it significantly reduced eosinophil infiltration, epithelial thickness of the nasal mucosa, and IL-4 cytokine levels.

Conclusion

The light emitted by the microneedle patch laser attached to the skin, penetrated effectively to the nasal mucosa within the nasal cavity, suggesting potential for treating allergic rhinitis in mice and could be extended in clinical applications.

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.