Yuzhu He, Yuxiang Chen, Shuang Xu, Yang Luo, Fengfeng Qin, Wenjian Hu
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引用次数: 0
摘要
背景:过敏性鼻炎(AR)是全球最常见的慢性疾病之一,在高收入国家的发病率高达 50%。AR患者常伴有流涕、鼻痒、鼻塞、打喷嚏、鼻黏膜水肿和苍白等症状,这些病变对患者的学习、睡眠和生活质量都有很大影响,常常给患者带来巨大的痛苦和经济负担。摘要:在目前治疗AR的方法中,免疫疗法能够取得令人满意的临床疗效。这表明了免疫细胞在 AR 中的重要性。然而,目前的疗法并不能完全治愈 AR。究其原因,目前对AR的研究主要集中在Th1和Th2免疫细胞在AR中的作用机制上,而忽视了其他关键细胞在AR中的作用:第 2 组先天性淋巴细胞、B 细胞、T 细胞和巨噬细胞可通过产生适当的细胞因子和介导炎症反应在 AR 的发病机制中发挥作用。M2 巨噬细胞可促进 AR 中的 Th2 细胞和嗜酸性粒细胞,从而增强 2 型炎症反应并进一步促进 AR。
Background: Allergic rhinitis (AR) is one of the most common chronic diseases worldwide, with prevalence rates as high as 50% in high-income countries. Patients with AR often have symptoms such as runny nose, itchy nose, nasal congestion, sneezing, and signs of edema and pallor of the nasal mucosa, and these pathologies have a major impact on the patient's learning, sleep, and quality of life, often resulting in significant pain and a huge economic burden for the patient.
Summary: Among the current treatments for AR, immunotherapy is able to achieve satisfactory clinical outcomes. This shows the importance of immune cells in AR. However, current therapies do not provide a complete cure for AR. The reason for this is that current research on AR focuses on the mechanism of Th1 and Th2 immune cells in AR, ignoring the role of other key cells in AR.
Key messages: Group 2 innate lymphoid cells, B cells, T cells, and macrophages can play a role in the pathogenesis of AR by producing appropriate cytokines and mediating the inflammatory response. M2 macrophages can promote Th2 cells and eosinophils in AR to enhance the type 2 inflammatory response and further promote AR.
期刊介绍:
''International Archives of Allergy and Immunology'' provides a forum for basic and clinical research in modern molecular and cellular allergology and immunology. Appearing monthly, the journal publishes original work in the fields of allergy, immunopathology, immunogenetics, immunopharmacology, immunoendocrinology, tumor immunology, mucosal immunity, transplantation and immunology of infectious and connective tissue diseases.