透明质酸-槲皮素共轭物的固态合成：提高槲皮素生物活性的可持续方案。

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2024-11-20 DOI:10.1002/cbdv.202402495

Valentina Verdoliva, Giuliana Muzio, Riccardo Autelli, Stefania De Luca

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引用次数: 0

摘要

本文采用了一种可持续固态程序，通过将透明质酸与疏水性槲皮素（HA-QCT）连接，合成了一种水溶性分子。考虑到槲皮素的多种生物活性，所开发的共轭物的胶束自聚集表明它可用作药物输送纳米系统。事实上，光谱表征（紫外-可见光和傅立叶变换红外光谱）确保了 QCT 保持其化学完整性。此外，细胞毒性测试表明，HA-QCT 可作为生物相容性药物载体用于药理学目的。初步的比色测试也证实了 QCT 保持了其抗氧化活性。

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Solid state synthesis of hyaluronic acid-quercetin conjugate: sustainable protocol to improve the biological activity of quercetin.

Herein, a sustainable solid-state procedure was employed for the synthesis of a water soluble molecule obtained d by linking hyaluronic acid to the hydrophobic quercetin (HA-QCT). The micellar self-aggregation of the developed conjugate suggested its employment as drug delivery nano-system, considering the numerous biological activities of QCT. Indeed, the spectroscopic characterization (UV-vis and FT-IR) ensured that the QCT maintained its chemical integrity. In addition, a cytotoxicity test revealed that HA-QCT could be employed as a biocompatible drug vehicle for pharmacological purposes. A preliminary colorimetric test also confirmed that QCT retained its anti-oxidant activity.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.