人体肾结石中镁稳定同位素的自然变化。

IF 2.9 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Metallomics Pub Date : 2024-12-02 DOI:10.1093/mtomcs/mfae056
Jinke Liu, Guilin Han, Yu Tian, Rui Qu, Di Wang, Yanan Shen
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引用次数: 0

摘要

肾结石是人体内产生的典型生物矿物,对人类健康构成重大威胁,影响着全球超过 12% 的人口。然而,人们对肾结石形成的确切机制并不完全了解。最近的金属同位素分析为研究金属阳离子在生物体内生物过程中的作用提供了一种新方法。在这里,我们首次报告了人类肾结石中的镁同位素比值。肾结石中δ26Mg的测量值总范围为1.05‰,从1.12‰到0.07‰不等。与密度泛函理论计算值相比,我们的数据显示出 24Mg 的显著富集。我们认为,体内的镁同位素分馏与肠道吸收过程中蛋白质介导的镁转运以及肾脏通过紧密连接蛋白对电离的 Mg2+ 的优先重吸收有关。我们的研究结果表明,镁对肾结石的抑制作用与结石阻断机制有关,水合镁的加入减轻了抑制作用的程度和同位素分辨的大小。我们的研究表明,金属同位素为我们揭示生物过程和人类健康的内在联系提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Natural variation of magnesium stable isotopes in human kidney stones.

Kidney stones, as typical biominerals produced within the human body, pose a significant threat to human health, affecting over 12% of the global population. However, the exact mechanisms underlying their formation are not fully understood. Recent metal isotopic analysis provides a new way to study the roles of metal cations in biological processes within organisms. Here, we report the Mg isotope ratios of human kidney stones for the first time. The total range of measured values for δ26Mg in kidney stones is 1.05‰, from -1.12‰ to -0.07‰. Our data exhibit a significant 24Mg enrichment compared with the values calculated from density functional theory. We suggest that the Mg-isotopic fractionations in vivo are linked to active Mg transport mediated by proteins during intestinal absorption and preferential renal reabsorption of ionized Mg2+ via tight junctional proteins. Our results indicate that the inhibitory effect of Mg on kidney stones is related to the kink-blocking mechanism, and the incorporation of hydrated Mg lessens the extent of inhibition and the magnitude of isotope discrimination. We show that metal isotopes provide new insights into the underlying biological processes and human health.

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来源期刊
Metallomics
Metallomics 生物-生化与分子生物学
CiteScore
7.00
自引率
5.90%
发文量
87
审稿时长
1 months
期刊介绍: Global approaches to metals in the biosciences
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