Loreana Gallo, Magali Bonne, Verónica Bucalá, María Esperanza Adrover
{"title":"利用介孔圣巴巴拉非晶-15 增强阿苯达唑的输送:箱式贝肯设计研究","authors":"Loreana Gallo, Magali Bonne, Verónica Bucalá, María Esperanza Adrover","doi":"10.1002/adem.202400320","DOIUrl":null,"url":null,"abstract":"<p>Over 70% of pharmaceutical compounds face the challenge of poor water solubility, which impacts on their bioavailability. This study focuses on the use of Santa Barbara Amorphous-15 (SBA-15) mesoporous silica material as carrier, which is synthesized and characterized to address this limitation. Albendazole (ABZ), an antiparasitic agent with low water solubility, serves as model drug. A Box-Behnken design (BBD) is used to investigate the impact of immersion method loading factors (temperature: 25–50 °C, time: 24–72 h, and SBA-15 amount: 83.2–252.0 mg) on drug loading percentage (DL%) and dissolution efficiency (DE%). The ABZ loading is confirmed by elemental analysis and Fourier transform infrared spectroscopy. Stability tests are performed, comparing drug dissolution profiles and X-ray diffraction patterns immediately after loading and after 12 months of storage at 25 °C and 60% relative humidity (RH%). DL% varies between 18% and 36% (w/w), showing that the amount of SBA-15 is the most significant factor on DL%. The lowest SBA-15 amount yielded the highest DL%. Regarding DE%, all the design samples exhibit higher values than pure ABZ, with the amount of SBA-15 being the primary influencing factor. Several samples from the BBD show high DE% (>70%) corresponding to high DL% values. After 12 months, most samples maintain similar dissolution profiles, demonstrating the good stability of the drug in the carrier over time. This study provides valuable insights into optimizing the loading process to enhance ABZ solubility and long-term stability using mesoporous SBA-15.</p>","PeriodicalId":7275,"journal":{"name":"Advanced Engineering Materials","volume":"26 22","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enhancing Albendazole Delivery Using Mesoporous Santa Barbara Amorphous-15: A Box-Behnken Design Study\",\"authors\":\"Loreana Gallo, Magali Bonne, Verónica Bucalá, María Esperanza Adrover\",\"doi\":\"10.1002/adem.202400320\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Over 70% of pharmaceutical compounds face the challenge of poor water solubility, which impacts on their bioavailability. This study focuses on the use of Santa Barbara Amorphous-15 (SBA-15) mesoporous silica material as carrier, which is synthesized and characterized to address this limitation. Albendazole (ABZ), an antiparasitic agent with low water solubility, serves as model drug. A Box-Behnken design (BBD) is used to investigate the impact of immersion method loading factors (temperature: 25–50 °C, time: 24–72 h, and SBA-15 amount: 83.2–252.0 mg) on drug loading percentage (DL%) and dissolution efficiency (DE%). The ABZ loading is confirmed by elemental analysis and Fourier transform infrared spectroscopy. Stability tests are performed, comparing drug dissolution profiles and X-ray diffraction patterns immediately after loading and after 12 months of storage at 25 °C and 60% relative humidity (RH%). DL% varies between 18% and 36% (w/w), showing that the amount of SBA-15 is the most significant factor on DL%. The lowest SBA-15 amount yielded the highest DL%. Regarding DE%, all the design samples exhibit higher values than pure ABZ, with the amount of SBA-15 being the primary influencing factor. Several samples from the BBD show high DE% (>70%) corresponding to high DL% values. After 12 months, most samples maintain similar dissolution profiles, demonstrating the good stability of the drug in the carrier over time. This study provides valuable insights into optimizing the loading process to enhance ABZ solubility and long-term stability using mesoporous SBA-15.</p>\",\"PeriodicalId\":7275,\"journal\":{\"name\":\"Advanced Engineering Materials\",\"volume\":\"26 22\",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Engineering Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adem.202400320\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Engineering Materials","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adem.202400320","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Enhancing Albendazole Delivery Using Mesoporous Santa Barbara Amorphous-15: A Box-Behnken Design Study
Over 70% of pharmaceutical compounds face the challenge of poor water solubility, which impacts on their bioavailability. This study focuses on the use of Santa Barbara Amorphous-15 (SBA-15) mesoporous silica material as carrier, which is synthesized and characterized to address this limitation. Albendazole (ABZ), an antiparasitic agent with low water solubility, serves as model drug. A Box-Behnken design (BBD) is used to investigate the impact of immersion method loading factors (temperature: 25–50 °C, time: 24–72 h, and SBA-15 amount: 83.2–252.0 mg) on drug loading percentage (DL%) and dissolution efficiency (DE%). The ABZ loading is confirmed by elemental analysis and Fourier transform infrared spectroscopy. Stability tests are performed, comparing drug dissolution profiles and X-ray diffraction patterns immediately after loading and after 12 months of storage at 25 °C and 60% relative humidity (RH%). DL% varies between 18% and 36% (w/w), showing that the amount of SBA-15 is the most significant factor on DL%. The lowest SBA-15 amount yielded the highest DL%. Regarding DE%, all the design samples exhibit higher values than pure ABZ, with the amount of SBA-15 being the primary influencing factor. Several samples from the BBD show high DE% (>70%) corresponding to high DL% values. After 12 months, most samples maintain similar dissolution profiles, demonstrating the good stability of the drug in the carrier over time. This study provides valuable insights into optimizing the loading process to enhance ABZ solubility and long-term stability using mesoporous SBA-15.
期刊介绍:
Advanced Engineering Materials is the membership journal of three leading European Materials Societies
- German Materials Society/DGM,
- French Materials Society/SF2M,
- Swiss Materials Federation/SVMT.