利用介孔圣巴巴拉非晶-15 增强阿苯达唑的输送:箱式贝肯设计研究

IF 3.4 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Loreana Gallo, Magali Bonne, Verónica Bucalá, María Esperanza Adrover
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引用次数: 0

摘要

超过 70% 的药物化合物面临着水溶性差的挑战,这影响了它们的生物利用度。本研究的重点是使用圣巴巴拉无定形-15(SBA-15)介孔二氧化硅材料作为载体,并对其进行合成和表征,以解决这一限制。阿苯达唑(ABZ)是一种水溶性较低的抗寄生虫药物,本研究以其为模型药物。采用方框-贝肯设计(BBD)研究了浸泡法负载因素(温度:25-50 °C,时间:24-72 小时,SBA-15 用量:83.2-252.0 毫克)对药物负载率(DL%)和溶解效率(DE%)的影响。通过元素分析和傅立叶变换红外光谱法确认了 ABZ 的负载量。在 25 °C 和 60% 相对湿度 (RH%) 下贮存 12 个月后,进行了稳定性测试,比较了装药后立即和贮存 12 个月后的药物溶解曲线和 X 射线衍射图样。DL% 在 18% 和 36% (重量比)之间变化,表明 SBA-15 的用量是影响 DL% 的最重要因素。SBA-15 用量越少,DL% 越高。关于 DE%,所有设计样品的数值都高于纯 ABZ,SBA-15 的用量是主要影响因素。BBD 的几个样品显示出较高的 DE%(70%),与较高的 DL% 值相对应。12 个月后,大多数样品都保持了相似的溶出曲线,这表明药物在载体中具有良好的长期稳定性。这项研究为使用介孔 SBA-15 优化负载过程以提高 ABZ 的溶解度和长期稳定性提供了宝贵的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Enhancing Albendazole Delivery Using Mesoporous Santa Barbara Amorphous-15: A Box-Behnken Design Study

Enhancing Albendazole Delivery Using Mesoporous Santa Barbara Amorphous-15: A Box-Behnken Design Study

Over 70% of pharmaceutical compounds face the challenge of poor water solubility, which impacts on their bioavailability. This study focuses on the use of Santa Barbara Amorphous-15 (SBA-15) mesoporous silica material as carrier, which is synthesized and characterized to address this limitation. Albendazole (ABZ), an antiparasitic agent with low water solubility, serves as model drug. A Box-Behnken design (BBD) is used to investigate the impact of immersion method loading factors (temperature: 25–50 °C, time: 24–72 h, and SBA-15 amount: 83.2–252.0 mg) on drug loading percentage (DL%) and dissolution efficiency (DE%). The ABZ loading is confirmed by elemental analysis and Fourier transform infrared spectroscopy. Stability tests are performed, comparing drug dissolution profiles and X-ray diffraction patterns immediately after loading and after 12 months of storage at 25 °C and 60% relative humidity (RH%). DL% varies between 18% and 36% (w/w), showing that the amount of SBA-15 is the most significant factor on DL%. The lowest SBA-15 amount yielded the highest DL%. Regarding DE%, all the design samples exhibit higher values than pure ABZ, with the amount of SBA-15 being the primary influencing factor. Several samples from the BBD show high DE% (>70%) corresponding to high DL% values. After 12 months, most samples maintain similar dissolution profiles, demonstrating the good stability of the drug in the carrier over time. This study provides valuable insights into optimizing the loading process to enhance ABZ solubility and long-term stability using mesoporous SBA-15.

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来源期刊
Advanced Engineering Materials
Advanced Engineering Materials 工程技术-材料科学:综合
CiteScore
5.70
自引率
5.60%
发文量
544
审稿时长
1.7 months
期刊介绍: Advanced Engineering Materials is the membership journal of three leading European Materials Societies - German Materials Society/DGM, - French Materials Society/SF2M, - Swiss Materials Federation/SVMT.
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