针对神经炎症的药物输送治疗脑部疾病

IF 4 2区 化学 Q1 BIOCHEMICAL RESEARCH METHODS
Juntao Wang, Ruiqin Jia, Wubo Wan, Haijun Han, Guoying Wang, Zhen Li* and Jia Li*, 
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引用次数: 0

摘要

脑部炎症是多种脑部疾病的标志。炎症过程在这些疾病中的复杂作用表明,神经炎症可能是一个有价值的治疗靶点。虽然已经发现了几种很有前景的抗炎药物,但它们在脑部疾病中的临床应用往往因无法穿过血脑屏障(BBB)并在病变部位达到治疗有效浓度而受到阻碍。这一局限性凸显了针对脑部炎症设计有效的 BBB 穿透性给药系统的迫切需要。这篇综述批判性地探讨了过去五年来旨在缓解阿尔茨海默病和缺血性中风--全球两大致死和致残原因--的脑部炎症的给药策略的最新进展。此外,我们还探讨了这一领域面临的主要挑战,并就针对神经炎症治疗脑部疾病的未来方向提出了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Drug Delivery Targeting Neuroinflammation to Treat Brain Diseases

Drug Delivery Targeting Neuroinflammation to Treat Brain Diseases

Inflammation within the brain is a hallmark of a wide range of brain diseases. The complex role of inflammatory processes in these conditions suggests that neuroinflammation could be a valuable therapeutic target. While several promising anti-inflammatory agents have been identified, their clinical application in brain diseases is often hampered by the inability to cross the blood-brain barrier (BBB) and reach therapeutically effective concentrations at the pathological sites. This limitation highlights the urgent need for effective BBB-penetrating drug delivery systems designed to target brain inflammation. This review critically examines the recent advances over the past five years in drug delivery strategies aimed at mitigating brain inflammation in Alzheimer’s disease and ischemic stroke─two of the leading causes of death and disability worldwide. Additionally, we address the key challenges in this field, offering insights into future directions for targeting neuroinflammation in the treatment of brain diseases.

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来源期刊
Bioconjugate Chemistry
Bioconjugate Chemistry 生物-化学综合
CiteScore
9.00
自引率
2.10%
发文量
236
审稿时长
1.4 months
期刊介绍: Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.
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