银（I）介导的二维 DNA 纳米结构

IF 13 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2024-11-20 DOI:10.1002/smll.202407604

Simon Vecchioni, Rainbow Lo, Qiuyan Huang, Kun Wang, Yoel P. Ohayon, Ruojie Sha, Lynn J. Rothschild, Shalom J. Wind

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引用次数: 0

摘要

DNA 结构纳米技术能够在纳米尺度上实现物质的自组织，但扩展这些支架的无机和电功能的方法仍然有限。核酸金属学的发展使 DNA 双链中特定位点金属离子的结合成为可能，并提供了一种以原子精度使双螺旋功能化的方法。本文介绍了一类二维 DNA 纳米结构，它将胞嘧啶-Ag+-胞嘧啶（dC:Ag+:dC）碱基对作为自组装的化学触发器。研究表明，Ag+-功能化 DNA 可按程序组装成大型阵列和环状结构，并可进一步与鸟嘌呤四骈合物（G4）共同组装。研究表明，二维 DNA 晶格可与各种嵌入式纳米线以可调间距组装在一起。这些结果为进一步开发自组装金属化 DNA 纳米结构奠定了基础，有望实现纳米间距的高精度 DNA 纳米电子学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Silver(I)-Mediated 2D DNA Nanostructures

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Silver(I)-Mediated 2D DNA Nanostructures

Structural DNA nanotechnology enables the self-organization of matter at the nanometer scale, but approaches to expand the inorganic and electrical functionality of these scaffolds remain limited. Developments in nucleic acid metallics have enabled the incorporation of site-specific metal ions in DNA duplexes and provide a means of functionalizing the double helix with atomistic precision. Here a class of 2D DNA nanostructures that incorporate the cytosine-Ag⁺-cytosine (dC:Ag⁺:dC) base pair as a chemical trigger for self-assembly is described. It is demonstrated that Ag⁺-functionalized DNA can undergo programmable assembly into large arrays and rings, and can be further coassembled with guanine tetraplexes (G4). It is shown that 2D DNA lattices can be assembled with a variety of embedded nanowires at tunable spacing. These results serve as a foundation for further development of self-assembled, metalated DNA nanostructures, with potential for high-precision DNA nanoelectronics with nanometer pitch.

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.